Niksan Pharmaceutical is a very well-known pharmaceutical in a field of medicines and API industries for Thiocolchicoside. We are the manufacturer, supplier, exporter and also trader of a large stock of Thiocolchicoside in Ankleshwar, Gujarat, India. Our product Thiocolchicoside is widely used and appreciated by our group companies and also our customers and users all around the nations. We offer the Thiocolchicoside in very affordable price. Niksan Pharmaceuticalsgroup company Niksan Healthcare is also a manufacturers and supplier of the Thiocolchicoside in all dosage form. Niksan Pharmaceuticalprovides Thiocolchicoside API in all over Indian states like Goa, Gujarat, Jammu and Kashmir, Jharkhand, West Bengal, Karnataka, Kerala, Madhya Pradesh, Maharashtra, Manipur, Meghalaya, Mizoram, Nagaland, Orissa, Punjab, Rajasthan, Sikkim, Tamil Nadu, Tripura and many other states. Niksan Pharmaceutical is manufacturing and exporting Thiocolchicoside from last many years in country like Reunion, France, Libya, Pakistan, Morocco, Tunisia, Kenya, Algeria, Greece, Vietnam, Ecuador, UAE, Turkey, Italy, UK, Germany, USA, Argentina, Armenia, Australia, Botswana, Brazil, Brunei, Colombia, Comoros, Congo Free State, Georgia, Germany, Ghana, Jamaica, Japan, Jordan etc. Thiocolchicoside is an anti-inflammatory drug which is used as muscle relaxant fortreatment of painful muscular conditions. Thiocolchicosideacts as a competitive GABA receptor antagonist and also glycine receptor antagonist which is use as a pain killer. SYNONYMS: TCC, Thiocolchicine 2-glucoside analog IUPAC NAME:N-[(10S)-3,4-dimethoxy-14-(methylsulfanyl)-13-oxo-5-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}tricycle hexadeca-1(16),2,4,6,11,14-hexaen-10-yl]acetamide CAS NO: 602-41-5 FORMULA: C27H33NO10S MOLECULAR MASS: 563.62 g/mol STORAGE OF THIOCOLCHICOSIDE:Store it at room temperature (25 to 30A C), and in an airtight container.Keep medicine away from the reach of children and pets. APPLICATIONS OF THIOCOLCHICOSIDE: Thiocolchicoside is used to treatment of Muscle spasm.Thiocolchicoside act as an anti-inflammatory drug which is used as muscle relaxant for treatment of painful muscular conditions.Thiocolchicoside works as a competitive GABA receptor antagonist and also glycine receptor antagonist which is use as a pain killer. HOW TO USE:Thiocolchicoside is available in tablet form so you can take this medicine by mouth. You can take Thiocolchicoside medicine every 12 hours up to 5 days. HOW THIOCOLCHICOSIDE WORKS: Thiocolchicoside act as a muscle relaxant by activating GABA inhibitory pathways.Thiocolchicoside is an anti-inflammatory drug which is used as muscle relaxant in the treatment of painful muscular conditions. CONTRAINDICATION OFTHIOCOLCHICOSIDE:If you have hypersensitivity to Thiocolchicoside kindly avoid this medicine.Kindly avoid this medicine during pregnancy and lactation. PHARMACOKINETICS OFTHIOCOLCHICOSIDE: Thiocolchicoside absorption is rapidly after oral administration.Half-life of Thiocolchicoside is approximately 5 to 6 hours.Average Peak Plasma Concentration of Thiocolchicoside is 49 mg/ml.Thiocolchicoside is mainly excreted by feces (79%) and 20% excreted by urine. SIDE EFFECTS OF THIOCOLCHICOSIDE: The most common side effect of Thiocolchicoside is allergy and vasovagal reactions.Other side effects are liver injury, pancreatitis, seizures, blood cell disorders,yellowing of skin and eyes, Photosensitivity, Dry mouth, Headache etc. Thiocolchicoside can often cause skin disorders like rhabdomyolysis, and reproductive disorders. In experimental animals, Thiocolchicoside is teratogenic.Sometimes Thiocolchicoside damages chromosomes. PRECAUTIONS: If you see any signs of liver toxicity like Abdominal pain in the upper right portion of the abdomen, Fatigue, Loss of appetite, Nausea and vomiting stop to taking Thiocolchicoside.If you have a diarrhoea during the administration of this drug kindly avoid medicine.Take this medicine during pregnancy and breastfeeding only if it is clearly needed. CDSCO APPROVAL: Diclofenac Sodium IP (as sustained release Pellets) 100mg + Thiocolchicoside (as sustained release pellets) 16mg Capsule. (New Dosage Form) is approved by CDSCO in India in 15.11.2011 Dexketoprofen Trometamol 25mg + Thiocolchicoside 4mg tablets are approved by CDSCO in India in 20.05.2010 Thiocolchicoside 8 mg + Etoricoxib 60 mg tablets are approved by CDSCO in India in 25.04.2009 Thiocolchicoside 4mg/8mg + Ketoprofen 50mg/100mg tablets are approved by CDSCO in India in 11.06.2008 Thiocolchicoside injection areapproved by CDSCO in India in 25.03.2004 Aceclofenac (100mg) + Thiocolchicoside (8 mg) tablets are approved by CDSCO in 03.08.2009 Aceclofenac (100mg) + Thiocolchicoside (4 mg) tablets (Additional strength) are approved by CDSCO in 11.08.2009 Etodolac 300/300mg +Thiocolchicoside 4/8mg are approved by CDSCO in 19.07.2010 Etodolac 400mg/400mg + Thiocolchicoside 4mg/8mg tablet are approved by CDSCO in 09.09.2010 Each sustained release tablet contains: Thiocolchicoside IP 8/16mg + Lornoxicam 8/16mg (Additional Strength) are approved by CDSCO in 08.04.2013 Thiocolchicoside 0.25% + Methyl salicylate IP 100mg + Menthol IP 50mg + Absolute alcohol IP 50mg per gm gel are approved by CDSCO in 11.10.2010 Diclofenac + Thiocolchicoside (50mg (EC) + 8mg) Capsules are approved by CDSCO in 21.10.2008 Aceclofenac IP (Sustained released pellets) 200mg/200mg + Thiocolchicoside IP (Sustained released pellets) 8mg/16mg Capsules. (New Dosage Form) are approved by CDSCO in 04.01.2012 Thiocolchicoside + Etoricoxib (4mg + 60 mg) FC Tablets are approved by CDSCO in 17.11.2008 Diclofenac + Thiocolchicoside (50 mg + 4 mg) Capsules are approved by CDSCO in 24.12.2008 S (+) Etodolac 300mg + Thiocolchicoside 8mg Tablet are approved by CDSCO in 05.01.2011 Lornoxicam 4mg/4mg + Thiocolchicoside 4mg/8mg tabletsare approved by CDSCO in 12.02.2010 Thiocolchicoside tablets are approved by CDSCO in 25.03.1996 Lornoxicam 8mg/8mg + Thiocolchicoside 4mg/8mg Tabletsare approved by CDSCO in 23.03.2010 FORMULATION AVAILABLE IN MARKET: Diclofenac Sodium IP (as sustained release Pellets) 100mg + Thiocolchicoside (as sustained release pellets) 16mg Capsules (New Dosage Form) Dexketoprofen Trometamol 25mg + Thiocolchicoside 4mg tablets Thiocolchicoside 8 mg + Etoricoxib 60 mg tablets Thiocolchicoside 4mg/8mg + Ketoprofen 50mg/100mg tablets Thiocolchicoside injection s Thiocolchicoside 0.25% + Methyl salicylate IP 100mg + Menthol IP 50mg + Absolute alcohol IP 50mg per gm gel Diclofenac + Thiocolchicoside (50mg (EC) + 8mg) Capsules Aceclofenac IP (Sustained released pellets) 200mg/200mg + Thiocolchicoside IP (Sustained released pellets) 8mg/16mg Capsules. (New Dosage Form) Thiocolchicoside + Etoricoxib (4mg + 60 mg) FC Tablets Diclofenac + Thiocolchicoside (50 mg + 4 mg) Capsules S (+) Etodolac 300mg + Thiocolchicoside 8mg Tablets Lornoxicam 4mg/4mg + Thiocolchicoside 4mg/8mg tablets Thiocolchicoside tablets Lornoxicam 8mg/8mg + Thiocolchicoside 4mg/8mg Tablets Aceclofenac (100mg) + Thiocolchicoside (8 mg) tablets Aceclofenac (100mg) + Thiocolchicoside (4 mg) tablets (Additional strength) Etodolac 300/300mg +Thiocolchicoside 4/8mg tablets Etodolac 400mg/400mg + Thiocolchicoside 4mg/8mg tablets Each sustained release tablet contains: Thiocolchicoside IP 8/16mg + Lornoxicam 8/16mg (Additional Strength) Note: Product protected by valid patents are not offered for sale in countries where such patents are still valid and its liability is at Buyers Risk. REFERENCES: https://pubchem.ncbi.nlm.nih.gov https://www.wikipedia.org/
