Cilostazol Ip/bp/ep/usp Application: Medicine

Niksan Pharmaceutical is the largest manufacturer and exporter of the Cilostazol among all over the world. Niksan Pharmaceutical is one of biggest the supplier, manufacturer, exporter and distributer of the Cilostazol API and finished formulations in Ankleshwar, Gujarat, India. The products of Niksan Pharmaceutical and Niksan group companies are widely appreciated by the clients and other companies.
Niksan Pharmaceutical provides API and finished formulations of Cilostazol in all over Indian states Like Kerala, Gujarat, Haryana, Rajasthan, Madhya Pradesh, Uttar Pradesh, Rajasthan, Karnataka, Meghalaya, Tamilnadu, Goa, Sikkim, Assam, Punjab, Delhi, Bihar, Jammu Kashmir Etc.
Niksan pharmaceutical is also large exporter of the API and finished pharmaceutical products of Cilostazol in many countries for years. The countries where we exporting are Puerto Rico, Brazil, Honduras, Argentina, Nicaragua, Philippines, Colombia, Guatemala, Uruguay, Mexico, Chile, Dominican Republic, Panama, South Korea, United States, El Salvador, Venezuela, Taiwan, Indonesia, Bolivia, Peru, Ecuador, Romania, Hong Kong, Thailand, United Arab Emirates, Iraq, Serbia, Spain, Bulgaria, Greece, Pakistan, Hungary, Portugal, Vietnam, Egypt, Iran, Poland, Czechia, Germany, Malaysia, Saudi Arabia, Canada, United Kingdom, Australia, Japan, Turkey, Italy and many more countries.
Cilostazol is belongs to drugs class called platelet-aggregation inhibitors. It is works by improving blood flow in legs. Cilostazol is anti-platelet type of drug and it also used as vasodilator.
Cilostazol stops blood cells to combine or stick together and inhibits blood clots. Cilostazol is used to increase the blood flow because of that the Oxygen flow in body also increases. Cilostazol is one type of vasodilators so it is also helps blood to flow smoothly in body.

SYNONYMS: Cilostazol, Cilostazole, Cilostazolum

IUPAC NAME:6-[4-(1-cyclohexyl-1H-1, 2, 3, 4-tetrazol-5-yl)butoxy]-1,2,3,4-tetrahydroquinolin-2-one

CAS NO: 73963-72-1

FORMULA: C20H27N5O2

MOLECULR MASS: 369.46 g/mol

STORAGE: Store it in cool and dry place, away from moisture and direct light. Does not store this medicine in bathroom or any humidly place. Keep medicine away from the reach of children and pets.

APPLICATIONS: Cilostazol is widely used as vasodilator. Cilostazol is also use in the treatment of intermittent claudication.Cilostazol also use to treat cramp, ache, fatigue, classically it is used in calf muscle during the workout.

HOW TO USE: Follow all directions on your prescription label or as your doctor recommends you. Take Cilostazol two times per day on an empty stomach. Take medicine at least 45 minutes or 2 hours before meal. Cilostazol takes time like 8-12 weeks to improve your symptoms. But if your symptoms do not improve after 3-4 weeks treatments tell you doctor. Try to take medicine at a same time each day to improve effectiveness.

HOW CILOSTAZOL WORKS: Cilostazol and Cilostazol metabolites are one type of posphodiesterase III inhibitors (PDA III inhibitors). Cilostazol inhibits activity of posphodiesterase and also quash cAMP degradation so by that cAMP increased in Blood vessels and platelets and by this activity the platelet degradation inhibits and also blood clotting reduced by the activity.

CONTRAINDICATIONS: Do not take Cilostazol medication if you have any heart problems like Congestive heart failure. Take your doctorAcA A s advice if you are pregnant or in lactation phase. Cilostazol can harm a nursing baby so do not take medication if you are breastfeeding a baby. Do not share your medication with other person. Take your doctorAcA A s recommendation if any adverse reactions appear while taking the treatment of Cilostazol.

PHARMACOKINETICS: Absorption of Cilostazol in gastrointestinal system is slow or incomplete. Cilostazol is absorbed after the oral administration. A high fat meal can increase the absorption of Cilostazol.The half-life of the Cilostazol is between 11-13 hours.The Cilostazol excreted almost 74-76% by urination and the remaining medicine 23-27% eliminate by the faces like sweating or by skin.

SIDE EFFECTS OF CILOSTAZOL: The common side effects of Cilostazol are headache, upset bowel movements, runny nose, normal rash, dizziness. There are some major side effects are also cause by the Cilostazol like difficulty in breathing, chest pain, swelling of (face, tongue, fingers, and throat). Take your doctorAcA A s instructions at the minute if you have symptoms like:
Fever, chills, body aches, flu symptoms.
Paining while urinating or bloody urine
Shortnessof breath, swelling of feet and fingers
Chest pain, irregular heartbeats

PRECAUTIONS: Do not take Cilostazol if you have heart problem. Cilostazol can make your problem worst.For the safety tell your doctor if you have any problem related liver or kidney. Avoid grapefruit juice or product.Do not take Cilostazol with Abacavir; it can increase the serum level.If Cilostazol is taken with Abciximab it can increase the severity of bleeding.

CDSCO APPOVAL:Cilostazol E.R. 100mg and 200mg tablets are approved by CDSCO in India in 30.10.2007.

FORMULATIONS AVAILABLE IN MARKET:
Cilostazole tablets 50mg (E.R. release)
Cilostazole tablets 100mg (E.R. release)
Cilostazol + L-Carnitine 100mg tablets

Note: Product protected by valid patents are not offered for sale in countries where such patents are still valid and its liability is at Buyers Risk

REFERENCES:

www.webmd.com
https://pubchem.ncbi.nlm.nih.gov
https://go.drugbank.com
https://cdscoonline.gov.in
https://www.wikipedia.org/
https://www.drugs.com
https://www.zaubacorp.com
https://www.practo.com/consult