Screening For Scfv/fab With Excellent Thermal Stability

Our organization hold expertise in providing services of Screening for scFv/Fab with Excellent Thermal Stability. Creative Biolabs offers specialized thermal stable antibody fragment (scFv/Fab) screening and antibody stability improvement services. With 10 years of experiences in antibody engineering and therapeutic antibody development, scientists in Creative Biolabs hold unparalleled expertise in phage display and yeast display scFv/Fab library construction and screening for thermodynamic properties such as thermal stability using high throughput approaches.
Stability is one of the most important functional requirements for the use of antibodies and antibody fragments in therapeutic and diagnostic applications. However, the non-ideal biophysical properties and insufficient thermal stability of antibody fragments such as scFv and Fab often leads to poor expression level, poor solubility and protein aggregation, which limits their potential as diagnostic and therapeutic agents. To fulfill our customersa requirements, Creative Biolabsa optimized strategies enable separation and screening of properly folded, active antibody fragments from culture supernatants under ordinary and a challengea temperatures simultaneously. After that, antibody fragments that reach the target stability as measured by melting temperature (Tm) can be identified. We normally obtain thermal stable Fab fragments with Tm at 70A C or higher in most of our screening projects.