Regonam Regorafenib Tablets 40 Mg

Regonam (Regorafenib)is an oralmulti-kinase inhibitorused to treat certain types of cancers by blocking enzymes (kinases) that promote cancer cell growth and tumor blood vessel formation.

Key Information:

* Generic Name:Regorafenib

* Strength:40 mg tablets

* Class:Multikinase inhibitor (targeted therapy)

* Route:Oral

Regorafenib 40 mg is indicated for the treatment of:

* Metastatic colorectal cancer (mCRC)after failure of prior treatments

* Gastrointestinal stromal tumors (GIST)after imatinib and sunitinib failure

* Hepatocellular carcinoma (HCC)in patients previously treated with sorafenib

Key Benefits:

* Slows progression of cancer by inhibiting multiple cancer-related kinases

* Improves progression-free survival

* Effective even after resistance to prior therapies

Regorafenib inhibitsmultiple protein kinases, including those involved in:

* Tumor angiogenesis (VEGFR1-3, TIE2)

* Oncogenesis (KIT, RET, RAF-1, BRAF)

* Tumor microenvironment (PDGFR, FGFR)

This leads todecreased tumor growth and reduced blood supply to tumors.

Dosage & Administration:

* Recommended Dose:160 mg once daily (i.e.,4 x 40 mg tablets)

* Dosing Cycle:3 weeks on treatment, 1 week off (28-day cycle)

* Takeafter a low-fat meal

* Swallow tablets whole with water

Common Side Effects:

* Fatigue, weakness

* Hand-foot skin reaction (palmar-plantar erythrodysesthesia)

* Diarrhea

* High blood pressure (hypertension)

* Loss of appetite, weight loss

* Voice changes (hoarseness)

* Liver enzyme elevation

Monitoring Required:

* Liver function tests (ALT, AST, bilirubin)

* Blood pressure

* Electrolytes

* CBC (Complete blood count)

* Signs of bleeding or infection

Precautions:

* Use with caution in patients withliver impairment

* Discontinue permanently ifsevere liver injuryoccurs

* Avoid inpregnancy & breastfeeding

* Watch forsigns of bleeding, wound healing issues, and infections

Drug Interactions:

* Interacts withCYP3A4inducers/inhibitors

* Avoidgrapefruit juice

* May affect levels of other drugs like warfarin, phenytoin, and digoxin

Tips for Patients:

* Take withlow-fat meals

* Do not crush or chew tablets

* Report anyliver issues, skin reactions, or unusual bleeding

* Stayhydratedand maintain goodhand-foot skin care

* Inform your doctor aboutall other medicationsand supplements.