Sunitex - Sunitinib Malate 50mg Capsule, High Strength Anti-cancer Medicine | 28 Capsules, Who-gmp Certified, Normal Smell, Cool & Dry Storage

Sunitinib Malate 50 mg Capsule is an oral anti-cancer
medicine used to treat several types of cancers by inhibiting specific enzymes
(tyrosine kinases) involved in tumor growth and blood vessel development.

Uses

Sunitinib is primarily prescribed for:

* Renal
Cell Carcinoma (RCC) advanced kidney cancer

* Gastrointestinal
Stromal Tumor (GIST) after failure with imatinib

* Pancreatic
Neuroendocrine Tumors (pNET) progressive, well-differentiated tumor

Mechanism of Action

Sunitinib is a multi-targeted tyrosine kinase inhibitor
(TKI). It

Inhibits
receptors like VEGFR, PDGFR, KIT, and FLT3

* Inhibits
receptors like VEGFR, PDGFR, KIT, and FLT3

* Blocks
tumor angiogenesis (formation of new blood vessels)

* Suppresses
tumor cell proliferation

Dosage and
Administration

* Standard
dose: 50 mg once daily

* Schedule:
4 weeks on treatment followed by 2 weeks off (4/2 cycle)

* Take
with or without food

* Dosage
adjustments may be required based on side effects or organ function

Common Side Effects

* Fatigue,
weakness

* Diarrhea,
nausea, vomiting

* Hand-foot
syndrome (redness, swelling, pain)

* High
blood pressure

* Skin
discoloration (yellowish skin or hair changes)

* Loss
of appetite, weight loss

* Mouth
sores

* Abnormal
liver function tests

Monitoring Parameters

Regular monitoring includes:

* Complete
blood counts (CBC)

* Liver
and kidney function tests

* Blood
pressure

* Thyroid
function

*Cardiac
function in some cases

Precautions

* Not
recommended during pregnancy or breastfeeding

* Caution
in patients with heart disease or liver impairment

* Avoid
grapefruit or grapefruit juice (can increase drug levels)

Drug Interactions

* CYP3A4
inhibitors (e.g., ketoconazole) Sunitinib levels

* CYP3A4
inducers (e.g., rifampin) Sunitinib effectiveness

* May
interact with anticoagulants, QT-prolonging drugs

* Patient Tips

* Take
exactly as prescribed; do not alter dose/timing

* Report
signs of bleeding, heart issues, or severe fatigue

* Use
effective contraception during treatment and for some time afterward

* Stay
hydrated and maintain good nutrition

* Notify
doctor about any new symptoms or other medications.