5-fluoropyrimidine (Cas 675-21-8)
Product Overview
Key Features
The function mechanism of 5-Fluoropyrimidine for cancer treatment
5-Fluoropyrimidines can induce DNA lesions. This will kill the cancer cells and thus cure cancer.
The process works via two different mechanisms. One of them involves incorporating drug into DNA, and the other does not involve the same incorporation. In the second mechanism, the detected DNA strand breaks is assumed to be a spontaneousa DNA lesions. It means the lesions are not repaired because of a lackage of a similar mechanism proposed for the induction of DNA lesions by methotrexate and hydroxyurea.
The cytotoxicity of 5-fluoropyrimidines in many cell lines has been correlated with exhaustion of dTTP pools secondary to inhibition of thymidylate synthase. It has been revealed that when dipyridamole changes the metabolism of 5-fluorouracil, a selective increase in 5-fluorodeoxyuridine monophosphate levels can be detected. This should further increase the inhibitory effect on thymidylate synthase.
Preparation of 5-Fluoropyrimidines
5-Fluoropyrimidines can be prepared fromA diethyl fluoromalonate or dimethyl fluoromalonate.
Company Details
Focusing on a customer-centric approach, Banff Green Technologies, Inc has a pan-India presence and caters to a huge consumer base throughout the country. Get Chemical Supplies from Banff Green Technologies, Inc at Trade India quality-assured services.
Business Type
Exporter, Manufacturer, Service Provider, Supplier, Trading Company
Establishment
2014
Seller Details
Banff Green Technologies, Inc
Name
Ms. Xue Yang
AddressView on Map
Floor 29, CapitaMalls Plaza, No. 6088 Humin Rd., Minhang Dist., Minhang, Shanghai, 201100, China
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