4-chloro-6-ethyl-5-fluoropyrimidine (Cas 137234-74-3)

Our organization manufacturing, exporting, trading and supplying 4-Chloro-6-Ethyl-5-Fluoropyrimidine (CAS 137234-74-3) in Minhang, Shanghai, China which is a building block and pharmaceutical intermediate for synthetizing bio-active compounds such as broad-spectrum triazole antifungal agents, specifically for producing Voriconazole.

Application of 4-chloro-6-ethyl-5-fluoropyrimidine for synthetizing Voriconazole
Voriconazole is synthetized in a process of condensing 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazole-1-yl)ethanone with 4-chloro-6-ethyl-5-fluoropyrimidine, in a ketone, ether, aliphatic hydrocarbon, or aromatic hydrocarbon solvent, to obtain (2R, 3S/2S,3R)-3-(4-chloro-5-fluoropyrimidin-6-yl)-2-(2,4-diflurophenyl)-1-(1H-1,2,4-triazole-1-yl)butan-2-ol.

Storage of 4-chloro-6-ethyl-5-fluoropyrimidine: Store under room temperature.