Tizanidine Tablets Ip By Marshall Healthcare

Tizanidine 2mg tablets are a medication primarily used as a skeletal muscle relaxant.

Here's a detailed description:

What it is used for:
Muscle Spasticity: Tizanidine is prescribed to relieve muscle spasms, cramping, and tightness caused by certain conditions affecting the brain or spinal cord.

These conditions include:
Multiple Sclerosis (MS)
Spinal cord injuries
Other neurological disorders

How it works (Mechanism of Action):
Tizanidine is a centrally acting alpha-2 adrenergic agonist. This means it works in the brain and spinal cord.

It functions by inhibiting the release of excitatory neurotransmitters (like norepinephrine, glutamate, and aspartate) from spinal interneurons.

This action helps to reduce hyperactivity in motor neurons, leading to decreased muscle spasticity and improved muscle movement.

It also has a modest impact on descending inhibitory pathways from the brain to the spinal cord, further contributing to muscle relaxation.

Dosage and Administration (for 2mg tablets):
Typical Starting Dose: 2 mg orally every 6 to 8 hours as needed.

Frequency: Generally, no more than 3 doses per day.
Titration: Your doctor may gradually increase the dose by 2 mg to 4 mg every few days, depending on your response and tolerability.

Maximum Dose: The maximum recommended single dose is 16 mg. The maximum total daily dose within a 24-hour period is 36 mg.

Consistency: It's important to take Tizanidine consistently, either always with food or always without food, as this can affect absorption. Do not switch between taking it with and without food without consulting your doctor.

Discontinuation: Do not stop taking tizanidine suddenly, especially if you've been on high doses for extended periods. Your doctor will likely advise a gradual decrease in dosage to prevent withdrawal symptoms like increased heart rate, high blood pressure, or increased muscle tightness.

Important Considerations:
Ingredients: Tizanidine 2mg tablets typically contain 2 mg of tizanidine (as tizanidine hydrochloride) and inactive ingredients such as microcrystalline cellulose, anhydrous lactose, colloidal silicon dioxide, and pregelatinized starch.

Allergies: Inform your doctor if you have any known allergies to tizanidine or any of its ingredients.

Medical Conditions: Discuss any history of kidney disease, liver disease, or heart problems with your doctor, as dosage adjustments or closer monitoring may be needed.

Drug Interactions: Tizanidine can interact with other medications, particularly strong inhibitors of CYP1A2 (like fluvoxamine and ciprofloxacin), which can significantly increase tizanidine levels and adverse effects. It can also have additive sedative effects with alcohol and other CNS depressants. Always inform your doctor and pharmacist about all medications you are taking, including over-the-counter drugs and supplements.

Pregnancy and Breastfeeding: Tizanidine is generally not recommended during pregnancy or breastfeeding unless the potential benefits outweigh the risks. Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Driving and Operating Machinery: Tizanidine can cause drowsiness, dizziness, and weakness. Avoid driving or operating machinery until you know how the medication affects you.

Lactose Intolerance: Many tizanidine tablets contain lactose. If you have an intolerance to certain sugars, discuss this with your doctor.