Tizanidine Hydrochloride - Off White To Light Yellow Powder, Soluble In Methanol And Water, Clear Solution With Impurity Limit Of 0.2%

Salius pharma is one of the largest exporter of pharmaceuticals from India based here in Mumbai
Tizanidine is Antispasticity Agents is used as a muscle relaxant. Tizanidine is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, spastic diplegia, back pain, or certain other injuries to the spine or central nervous system.
Tizanidine hydrochloride
Synonyms : 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-Benzothiadiazol-4-amine monohydrochloride; 5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole hydrochloride; Sirdalud; Ternelin; Tizan; Zanaflex
CAS Registry Number : 64461-82-1
Molecular Formula : C9H8ClN5S . ClH
Molecular Weight : 290.17

Specification of Tizanidine HydroChloride

Description :- Off white to light yellow color powder

Solubility:- Soluble in Methanol and water

Identification:- By IR

Melting Point:- 285oC to 290oC

Acidity: - pH of 5% w/v solution is 3.5 to 5.0

Heavy Metals :- Not more than 20PPM

Loss on drying :- Not more than 0.5%

Sulphate Ash :- Not more than 0.2%

Clarity & Color of Solution:- A5% w/v solution in water is clear and free from visible foreign particles and absorbance at 420nm is not more than 0.25
Related substances By HPLC:-
1] Individual impurity : Not more than 0.2 %
2] Total Impurities : Not more than 1.0 %

Assay by HPCL:- Not less than 98.0 % and not more than 102.0 % w/w of C9H8CIN5S.