Rosuvastatin 10/20 Mg

Rosuvastatin
Rosuvastatin structure.svg
Rosuvastatin-3D-balls.png
Clinical data
Pronunciation/roA A A A suA A vA A stA A tA Aan/ roh-SOO-vA A -stat-in
Trade namesCrestor, Rosulip, Zuvamor
AHFS/Drugs.comMonograph
MedlinePlusa603033
Pregnancy
category
AU: D
US: X (Contraindicated)
Routes of
administrationBy mouth (tablets)
ATC code
C10AA07 (WHO)
Legal status
Legal status
AU: S4 (Prescription only)
UK: POM (Prescription only)
US: AcA A -only
In general: AcA A (Prescription only)
Pharmacokinetic data
Bioavailability20%[1]
Protein binding88%[1]
MetabolismLiver: CYP2C9 (major) and CYP2C19-mediated; ~10% metabolized[1]
MetabolitesN-desmethyl rosuvastatin (major; 1/6AcA A 1/9 of rosuvastatin activity)[2]
Elimination half-life19 hours[1]
ExcretionFaeces (90%)[1]
Identifiers
IUPAC name[show]
CAS Number
287714-41-4 Yes
PubChem CID
446157
IUPHAR/BPS
2954
DrugBank
DB01098 Yes
ChemSpider
393589 No
UNII
413KH5ZJ73
KEGG
D01915 No
ChEBI
CHEBI:38545 No
ChEMBL
CHEMBL1496 No
PDB ligand
FBI (PDBe, RCSB PDB)
ECHA InfoCard100.216.011 Edit this at Wikidata
Chemical and physical data
FormulaC22H28FN3O6S
Molar mass481.539
3D model (JSmol)
Interactive image
SMILES[show]
InChI[show]
NoYes (what is this?) (verify)

Rosuvastatin , is a member of the drug class of statins, used in combination with exercise, diet, and weight-loss to treat high cholesterol and related conditions, and to prevent cardiovascular disease.