Eltrombopag Olamine - White Powder, Cas No: 496775-62-3 | 99.7% Purity, Medicine Grade, Odorless, Heavy Metals <10ppm, Megakaryopoiesis-stimulating Activity

Product name Eltrombopag Olamine

Cas number 496775-62-3

Molecular formula C29H36N6O6

Molecular weight 564.63300

Appearance Powder
Specification
ItemStandardResults
Identification A.H-NMR: comply with the structure

B.LC-MS: comply with the structure

C. The IR spectrum of sample should be identical with taht of reference standard

D.HPLC-ESI-MS: The retention time of the major peak in the chromatogram of the assay preparation corresponds to that in the chromatogram of the standard preparation ,as obtained in the assay.Complies

Complies

Complies


Complies
Heavy metalsa 10 ppm<10ppm
Watera 1.0%0.10%
Sulphated asha 0.5%, determined on 1.0 g.0.01%
Related substancesUnspecified impurities: for each impurity a 0.1%
Total impurity a 0.5%<0.10%
0.18%
Puritya Y99.0%99.7%
Assay99.0%~101.0% (anhydrous substance).99.85%
StoragePreserve in well-closed, light-resistant and airtight containers.Complies
Function
Eltrombopag Olamine is the orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrombopag binds to and stimulates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110), a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an increase in platelet production.