Bortemed Bortezomib Injection 2mg - Origin: India

Bortezomib 2mg Injection Overview

* Generic Name:Bortezomib

* Strength:2 mg

* Route:Intravenous (IV) or Subcutaneous (SC) injection

* Drug Class:Proteasome inhibitor

* Schedule:Administered under medical supervision in oncology settings

Use:

* Multiple Myeloma(alone or in combination with other drugs)

* Mantle Cell Lymphoma(in patients who have received at least one prior therapy)

Key Benefits:

* Targets and destroys cancer cells by interfering with protein breakdown

* Improvesprogression-free survivalandoverall survivalin multiple myeloma

* Works well in combination with other chemotherapy agents

* Can be given as an outpatient procedure

Bortezomibinhibits the 26S proteasome, an enzyme complex responsible for degrading unwanted or misfolded proteins.

* This leads to theaccumulation of proteinswithin cancer cells, causingcell cycle arrest and apoptosis (cell death).

* It alsodisrupts symbols pathwaysessential for cancer cell survival, especially inmultiple myeloma cells.

Dosage & Administration:

* Typical Dose:1.3 mg/m body surface area

* Frequency:Twice weekly for 2 weeks followed by a 10-day rest (in 21-day cycles), or as per protocol

* Route:

* IV (intravenous)over 35 seconds OR

* SC (subcutaneous)into the thigh or abdomen

* Hydration and antiviral prophylaxis(e.g., acyclovir) may be advised

Dose adjustments required forhepatic impairment,renal failure, orsevere side effects

Common Side Effects:Fatigue, nausea, vomiting,Peripheral neuropathy(tingling, numbness in hands/feet), Diarrhea or constipation, Low blood counts (anemia, neutropenia, thrombocytopenia), Fever, infections, Headache, Rash, Dizziness or orthostatic hypotension Monitoring:

* Complete Blood Countregularly

* Liver function tests

* Renal function

* Monitor forneuropathy symptoms

* Watch for signs ofinfections,bleeding, andhypotension

Precautions:

* Use with caution in patients with:

* Liver dysfunction

* Peripheral neuropathy

* Heart disease

* Avoid duringpregnancy and breastfeeding

* Usecontraceptionduring and for several months after treatment

* Increased risk ofHerpes zoster reactivation prophylaxis may be recommended

Drug Interactions:

* CYP3A4 inhibitors (e.g., ketoconazole) may increase toxicity

* CYP3A4 inducers (e.g., rifampin) may reduce efficacy

* Care withhypotensive agents,anticoagulants, andimmunosuppressants

Tips for Patients:

* Reportnumbness, burning, or tingling sensations

* Avoid alcohol and cold temperatures if neuropathy develops

* Stay hydrated and eat light meals

* Report anyfever, bleeding, or bruising

* Attend all scheduledlab tests and follow-ups

* Rest well and avoid infections during low blood count periods