Ripasudil Eye Drops 0.4% W/v - Product Type: General Medicines

Ripasudil eye drops are a type of ophthalmic medication used primarily to treat glaucoma and ocular hypertension (high pressure in the eye).

Here is a detailed description:

Drug Class and Mechanism of Action:

Ripasudil belongs to a class of medications called Rho-kinase (ROCK) inhibitors.

Its unique mechanism of action is to lower intraocular pressure (IOP) by increasing the drainage of fluid (aqueous humor) from the eye.

It achieves this by inhibiting the Rho-kinase enzyme, which causes the relaxation of the trabecular meshworka the tissue in the eye responsible for draining the fluida thereby enhancing the conventional outflow facility through Schlemm's canal.

Primary Uses:

Glaucoma (specifically open-angle glaucoma): To lower the elevated IOP, which can otherwise damage the optic nerve and lead to vision loss.

Ocular Hypertension: To reduce the high fluid pressure in the eye, which is a major risk factor for developing glaucoma.

It is often used when other IOP-lowering medications (like prostaglandin analogs or beta-blockers) are insufficient or cannot be used.

Dosage and Administration:

It is typically administered as an ophthalmic solution (eye drops), often in a 0.4% concentration.

The usual dosage is one drop instilled into the affected eye(s) twice daily (morning and evening).

Note: This is a prescription medication, and the exact dosage and frequency should always be followed as prescribed by a healthcare professional.

Common Side Effects:

The most frequent side effect is conjunctival hyperemia (eye redness), which is usually mild, transient, and subsides spontaneously within a few hours.

Other common side effects include eye irritation, inflammation of the conjunctiva (conjunctivitis), and inflammation of the eyelids (blepharitis).

Additional Potential Use:

While primarily approved for glaucoma, studies have suggested that Ripasudil may also have a protective effect on the corneal endothelium and promote wound healing, which could be beneficial in other corneal diseases or after eye surgeries like cataract removal.






The key active ingredient in ripasudil eye drops is Ripasudil hydrochloride hydrate.

It is a specific Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor, which is used to treat glaucoma and ocular hypertension.