Navolum 10 Tablets

We manufacture, export and supply a remarkable range of Navolum 10 Tablets from Wadhwan, Gujarat, India. In fasting subjects, domperidone is rapidly absorbed after oral administration, with peak plasma concentrations at 30 to 60 minutes. The low absolute bioavailability of oral domperidone (approximately 15%) is due to an extensive first-pass metabolism in the gut wall and liver. Although domperidone bioavailability is enhanced in normal subjects when taken after a meal, patients with gastro-intestinal complaints should take domperidone 15-30 minutes before a meal. Reduced gastric acidity impairs the absorption of domperidone. Oral bioavailability is decreased by prior concomitant administration of cimetidine and sodium bicarbonate. The lime of peak absorption is slightly delayed and the AUC somewhat increased when the oral drug is taken with l meal.

Each film coated tablet contains:
Domperidone Maleate BP
Equivalentto Domperidone 10 mg
Excipients q.s.
Colour : Tartrazine Lake &Titanium Dioxide
CHEMICAL NAME: 5-chloro-1-[1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1- yl)propyl] piperidin-4-y1]-1,3-dihydro-2H-benzimidazol-2-one hydrogen (Z)- butenedioate.
CATEGORY: Antiemetic.