Doxofylline Ip/bp/ep/usp Cas No: 69975-86-6

Niksan Pharmaceuticalis words top leading manufacturer, exporter, trader and supplier of DoxofyllineAPI as well as finished pharmaceutical products of Doxofyllineamong the pharmaceutical companies. Our product Doxofylline is widely used and appreciated by our group companies and also our customers and users all around the nations. We offer the Doxofylline in very affordable price. Niksan Pharmaceuticaland Niksan group companies are the very well-known manufacturers, suppliers and distributors of Doxofyllineproducts. Niksan Pharmaceuticalare manufacturing and exporting very large quantity of Doxofyllinein countries like Philippines, Bangladesh, Nepal, Pakistan, Thailand, United states, Paraguay, Argentina, Dominican Republic, Sudan, Hong Kong, Seychelles, Algeria, Iran, Bulgaria, Lithuania, Poland, Sri Lanka, Romania, Uruguay,Serbia, New Zealand, Sweden, Hungary, Mauritius, Vanuatu, Malta, Kazakistan, Slovenia, Bolivia, Japan, Russia, Afghanistan, Latvia, Lithuania, United Arab Emirates, Seychelles, Peru, Switzerland, Tunisia, France, Chile, South Korea, United Kingdom, Australia, Greece, Austria and Germany. Doxofylline is one type of anti-asthmatic drug. Doxofylline is belongs to the Bronchodilator type of medicine. Mainly Doxofylline is widely used in a treatment of chronic obstructive pulmonary disease (COPD) and also used to treat asthma. Doxofyllineis also called xanthenes derivative drug which is used in breathing problems. We can say that Doxofylline makes breathing easier. Doxofylline acts as a posphodiesterase inhibitor which can use in bronchospasm and other respiratory disorders. SYNONYMS: Doxofilina, Doxofylline, Doxophylline. IUPAC NAME:7-[(1,3-dioxolan-2-yl)methyl]-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2, 6-Dione CAS NO: 69975-86-6 FORMULA: C11H14N4O4 MOLECULAR MASS: 266.25 g/mol STORAGE:Doxofylline is mainly comes in crystalline form so store in a cool and dry place.Do not store in moistly or wet place like bathroom or kitchen.Keep the medicine away from reach of children and pets.Store the medication as directed by your doctor. APPLICATION OF DOXOFYLLINE:Doxofylline is an antitussive medicine which is mostly used in a treatment of asthma and other respiratory problems.Doxofylline shows fewer side effect then the other xanthine type of medicine, thata s why Doxofylline chosen over the other xanthine class drug. HOW TO USE: Doxofylline comes in two dosage forms one is Tablet and Syrup. Simply take Doxofylline tablet or syrup by mouth (orally) with food or without food.The prescribed dose of Doxofylline must be1200mg per day.Try to take medicine at a same time every day for the better improvement. HOW DOXOFYLLINE WORKS: The main mechanism of action of Doxofylline is not well known but we can say that theDoxofylline works by inhibiting the posphodiesterase activity, by this process the cAMP level raises and by this the smooth muscle relaxation occurs. CONTRAINDICATIONS OF DOXOFYLLINE:If you have hypersensitivity kindly avoid Doxofylline and chose alternative medicine.Kindly avoid the Doxofylline medication if you have any liver or kidney related problems or if you have any hypoxemia (low O2 level in blood) or have any cardiac arrhythmias.Before the writing of prescription tell your doctor if you have history of peptic ulcer or hyperthyroidism. PHARMACOKINETICS OF DOXOFYLLINE: Doxofylline working very differently in the body by that after taking of the regular dose Doxofylline reaches in steady state in about 4 days. The absolute bio availability of Doxofylline is 63A 25%. Basically methylxanthines are distributed into all over body compartment. The residues of Doxofylline are found in breast milk also.Doxofylline undergoes hepatic metabolism in which 90% of the drug clears from the body.Doxofylline is orally administered drug is only 4% excreted by the urination, the remaining drug will excreted in faces. SIDE EFFECTS OF DOXOFYLLINE: There were very less side effects of Doxofylline are noticed, most of them are very common side effects like nausea, vomiting, headache, obsess with food or anorexia.There are other side effects of Doxofylline like heart burn, dyspepsia are the notable side effects. PRECAUTIONS OF DOXOFYLLINE: Tell your doctor if you have any history of peptic ulcer or hyperthyroidism.Kindly do not take Doxofylline if you have any liver or kidney problem. CDSCO APPROVAL: Doxofylline tablet (20mg and 400mg) tablets are approved by CDSCO in India in 31.08.2005. Doxofylline syrup (20mg/ml) is approved by CDSCO in India in 31.08.2005. Doxofylline Syrup (20mg/ml) is approved by CDSCO in India in 30.03.2006. Doxofylline Tablet (400mg) is approved by CDSCO in India in 08.02.2006. Doxofylline ER tablets (400mg/800mg) are approved by CDSCO in India in 12.03.2008. Doxofylline 400 mg + Ambroxol 30 mg Tablets are approved by CDSCO in India in 23.12.2009. Doxofylline MR Tablet (650mg) is approved by CDSCO in India in 11.03.2010. FORMULATION OF DOXOFYLLINE AVAILABLE IN MARKET: Doxofylline tablets 20mg Doxofylline tablets 400 mg Doxofylline syrup 20mg/ml Doxofylline ER tablets 400mg Doxofylline ER tablets 800mg Doxofylline 400 mg + Ambroxol 30 mg tablets Doxofylline MR Tablets 650mg Note: Product protected by valid patents are not offered for sale in countries where such patents are still valid and its liability is at Buyers Risk REFERENCES: https://pubchem.ncbi.nlm.nih.gov https://www.wikipedia.org/