Metallo Beta Lactamase Dosage Form: Powder

Metallo-I -Lactamase (MBL) is produced by genetic engineering technology. It is expressed in recombinant E.coli and highly purified to homogeneity. The enzyme can hydrolyze I -Lactam ring of lactam antibiotics especially that in monocyclic I -lactams. The hydrolysis makes the antibiotics lose their anti-microbial activity. The product has specificity and can hydrolyze imipenem meropenem ertapenem and other antibiotics I -lactam ring. It also can hydrolyze penicillin sodium cefixime cefoperazone cefotaxime ceftriaxone cefoxitin etc. After radiation the lyophilized powder is finally sterilized.

Appearance: White or pain white lyophilized powder.
Package: 2 MU/bottle

Specifications:
Activityi a Y2 MU/ml.
Purityi > 95 % by SDS-PAGE
Sterilityi Negtive
pHi 6.0~8.0 after dissolved

Unite definition: One unit is defined as the amount of enzyme required to hydrolyze one biological unit of penicillin G in one hour at pH 7.0 37E C.

Application:
Environmental monitoring of antibiotic manufacturing areas;
Sterility testing of bulk Antibiotics;
Testing sterility of blood cultures;
Testing for I -lactam contamination of drugs.

Note:
0.1mM Mg2+and 0.1mM Zn2+play an important role in the enzyme activity;
Avoid violent oscillation and prevent a large number of bubbles during resuspension.
Stability: Stable at 2~8a for more than two years since report.