Zopen - E

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ZOPEN-E (Ertapenem 1gm Injection):

Ertapenem is a carbapenem antibiotic, structurally very similar to meropenem. Other members of the carbapenem group (imipenem, doripenem, and meropenem) are broadly active antibacterials but they have very short serum half-lives and must be administered by intravenous infusion every 6 to 8 hours. Ertapenem differs from other carbapenems in having a somewhat less broad spectrum of activity and extended serum half-life which allows it to be administered once every 24 hours.

Unlike imipenem and meropenem, ertapenem is highly protein-bound, which results in a longer half-life.

Ertapenem is excreted primarily (80%) by the kidneys. Metabolism by the liver is not clinically important and does not affect dosing.