Glipizide Granules

These Glipizide Granules are an oral medium-to-long acting anti-diabetic drug from the sulfonylurea class. It is classified as a second generation sulfonylurea, which means that it undergoes enterohepatic circulation.

The structure on the R2 group is a much larger cyclo or aromatic group compared to the 1st generation sulfonylureas. This leads to a once a day dosing that is much less than the first generation, about 100 fold.

Mechanism of action is produced by blocking potassium channels in the beta cells of the islets of Langerhans. By partially blocking the potassium channels, it will increase the time the cell spends in the calcium release stage of cell signaling leading to an increase in calcium.

The increase in calcium will initiate more insulin release from each beta cell.

Available Form:
We also offer Sustained (SR) / Immediate (IR) / Timed (TR) / Controlled (CR) / Delayed Release (DR) and Enteric Coated (EC).

Umang Pharmatech equipments used for production of Glipizide Granules:
DRUG LAYERING : Glipizide granules can be made by Drug layering method by a suitable drug layering equipment Made by UMANG PHARMATECH, The powder is sprinkled from one side in a drug layering machine and liquid from the other side.

FLUID BED DRYER : Glipizide granules can be dried in a fluid bed dryer.

SEIVING AND BLENDING : All granules are seived to a particular size and blended into a batch to suit the customer size and capsule fill weight required.