Vandetanib (Azd6474)

We are offering our customers a wide range of Vandetanib (AZD6474), which are available following Specifications :-
Synonymsi AZD6474,Zactima
CAS No.i 443913-73-3
Molecular Formulai C22H24BrFN4O2
Molecular Weighti 475.35
Solubilityi DMSO
Appearancei White powder
Purityi >99%
Chemical Name: 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline
Biological Activity:
Vandetanib (AZD6474) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine kinase activity, respectively. In vitro, two cell lines (OZ and HuCCT1), both of which harboured KRAS mutation, were refractory to vandetanib, one cell line (TGBC24TKB) was somewhat resistant, and another cell line (TKKK) was sensitive. The most sensitive cell line (TKKK) had EGFR amplification. Vandetanib (25a mga /kg/a day) significantly prolonged the time to metastasis in an intravenous model of TKKK metastasis.