Ap24534 (Ponatinib)

We are offering our customers a wide range of AP24534 (Ponatinib), which are available following Specifications :-
Synonymsi Ponatinib
CAS No.i 943319-70-8
Molecular Formulai C29H27F3N6O
Molecular Weighti 532.56
Solubilityi Soluble to 100 mM in DMSO and to 50 mM in ethanol
Appearancei White powder
Purityi >99%
Alternative Name: Ponatinib

Chemical Name: 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide

Biological Activity

Potent multi-kinase and pan-BCR-ABL inhibitor. Displays potent activity against cell lines expressing native BCR-ABL or BCR-ABLT3151 (IC50 values are 0.37 and 2.0 nM respectively); also inhibits other ABL kinase domain mutants at nanomolar potencies. Exhibits inhibitory activity against PDGFRI , c-Src and c-Kit (IC50 values are 1.1, 5.4 and 12.5 nM respectively); potently inhibits FGFR and VEGFR family kinases. Orally active.