Ft Plus

Folic acid suspension was prepared according to hospital formulation. The oral suspensions were divided into bottles labeled A,B,C stored at 25C (room temperature) and bottled labeled E,F,D and stored at 4C (refrigerated). The suspension was then scored for changes in visual appearance, odor, pH and microbial growth on Day 0, 7,14,30,60 and 90.

The folic acid suspension retained its colour and opaquecity from day 0 to day 90. There were no visible changes in colour or odour of folic acid suspension throughout the study. The samples pH was constant from day 0 to day 60 at pH 5.0. However the pH was deranged at day 90. pH of sample A and sample C which was stored at 25c increased from pH 5.0 to pH 5.5 and 6.0 respectively while only 1 sample E stored at 4c increased from pH 5.0 to pH 5.5 . The test scored positive once out of 108 samples tested for microbial growth which is sample F (store 4c) on Sabauroud dextrose agar for test on day 7.