Diclofenac Sodium - Purity 99%, Molecular Weight 318.1 G/mol | Anti-inflammatory And Analgesic Properties, Stabilizes Transthyretin Fibrils

Diclofenac Sodium is the salt form of Diclofenac, an active metabolite of the said Aceclofenac (sc - 217557). Hydrolysis of Aceclofenac, an inhibitor of interleukin - 1b - induced prostaglandin e2 production with no inhibitory activity against COX (Cyclooxy Genase), generates Diclofenac, which inhibits both cox-1 and oxidation of Diclofenac produces the metabolite Ha -Hydroxy. Diclofenac demonstrates specific inhibition. Inhibition of cox by Diclofenac and ha -hydroxy diclofenac suppress Protaglandin e2 synthesis, producing anti inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native Tetrameric conformation of Transthyretin (TTR) fibrils, preventing the formation of insoluble Amyloidogenic TTR deposits.

Description :
a cCas no. : 15307-79-6
a cMolecular weight : 318.1
a cMolecular formula : C14H10CL2NO2NA
a cWhite Solid
a cPurity : 99%
a cSolubility : Soluble in Ethanol DMSO or DMF (35MG/ML), soluble in buffers of ionic strength 0.1M AND PH 7.2 (9MG/ML)
a cBoiling point : H12 degree Celsius
a cBoiling point pressure : 203 degree Celsius
a cMelting point : 288 - 290 degree Celsius
a cVapor pressure : 1.59 E - 07MM HG at 25 degree Celsius
a cUV absorption : MAY 285 NM