Ceramide Pc-104 at Best Price in Cheongwon-gun, Chungbuk

Ceramide Pc-104

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Product Specifications

Product Type	Skin Lipid
Chemical Name	Ceramide PC-104
Purity	>95%
LD50	>5g/kg
Skin Irritation	0.16
Usage	Cosmetic ingredient for skin and hair care, improving barrier function and reducing TEWL.
Appearance	Crystalline powder
Features	Skin barrier repair, Moisture retention, Emollient effect, Anti-aging, Hair growth

Product Overview

Key Features

Introduction to Ceramide

The most important lipids of the barrier function in Stratum corneum.
Decrease transepidermic water loss and Increase the cohesion of upper layers of the epidermis.r
Make up about 40% to 65% of the total skin lipids.

General Features

Consist of 6 heterogeneous classes.

Contain sphingosine or phytosphingosine base in amide linkage with non-hydroxy, I -hydroxy or I -hydroxy fatty acids.

Sources of Ceramide

Animal	- High conc. present in brain, spinal cord and skin. - Mainly extracted from bovine or swine. - BSE
Plant	- from Soy bean etc. - Too small quantity, Less efficient
Microorganism	- from Yeast, Very expensive
Organic synthesis	- Various structure, Low price

Synthesis of Ceramide PC 104

Restoration effect on SDS-induced skin damage

Sample	Reduction ratio(%)*
Sample	7hr	24hr
Ceramide PC-104	19.5	39.1
Compound II	18.9	38.2
Compound III	19.2	37.9
Compound IV	17.7	32.9
N-Oleoylphytoshingosine	19.0	39.2
Base lotion	17.5	25.3
Control	15.7	19.9

* Before ceramide application, 2.5% SDS was treated for 30 min. under occlusion and rinsed
with warm water
* % reduction : (Tb - Ta) / Tb x 100 Tb : initial TEWL(base line), Ta : after application TEWL

Histopathological Findings
(Effect on 2.5% SDS damaged skin of Hairless Guinea Pig)

Restoration effect on Acetone-induced skin damage

Sample	Reduction ratio(%)*
Sample	4hr	8hr
Ceramide PC-104	40.2	57.3
Compound II	37.5	48.3
Compound III	38.2	55.2
Compound IV	27.3	45.2
N-Stearoylphytoshingosine	31.5	49.1
Vehicle	7.1	36.2

* Before ceramide application, Acetone was treated for 5 min. under occlusion and rinsed with
warm water
* % reduction : (Tb - Ta) / Tb x 100 Tb : initial TEWL(base line), Ta : after application TEWL

TEWL Comparison after Acetone Treatment

Sample	1hr	2hrs	4hrs	6hrs	8hrs
Non-treat	141.3	124.7	96.6	85.4	75.7
Vehicle	126.2	116.6	93.4	80.2	79.2
N-oleoylsphingosine	130.7	126.6	95.3	80.0	77.6
Ceramide PC-104	136.1	128.8	106.1	86.1	80.1
Mix, N-oleoylsphingosine	127.6	107.2	88.2	57.9	56.8
Mix, Ceramide PC-104	108.0	78.7	62.0	56.3	54.2

Vehicle ; PG : EtOH (7:3), using 1% mixture of ; Cholesterol : Ceramide :
Linoleic Acid : Palmitic Acid (1:1:1:1)

Dependence of liquid crystal formation on chain length

Safety data of Pseudoceramides

Sample	LD50	Primary skin irritation	Irritancy
N-oleoylphyto sphingosine	>5g/kg	0.17	No irritation
CeramidePC-104	>5g/kg	0.16	No irritation
Compound II	>5g/kg	0.25	No irritation
Compound III	>5g/kg	0.30	No irritation
Compound IV	>2/kg	2.51	Irritation

Applications

Moisture retaining effect

Emollient effect

Barrier function

Anti-aging

Cure for rough skin

Stratum Corneum turn-over function

Activation of skin function

Hair care

Hair growth promotion

Hair loss prevention

Amino acid, protein stabilization

Improve hair and nail function

Anti-dandruff

Conclusion

enhance the restoration of skin barrier

facilitate lamellar phase liquid crystal formation

high water holding capacity

the shorter alkyl chain length,

the lower emulsion viscosity and liquid crystal density

recovers damaged skin to normal state

non-irritable

Commercialized Ceramide Series

Ceramide PC-104	1,3-bis(N-2-(hydroxyethyl)palmitoylamino)-2-hydroxy propane INCI Name : Hydroxypropyl Bispalmitamide MEA Powder, For Emulsifying product
Liquid Ceramide	Ceramide 20% Liquid Crystal Base For Easy Formulation
Ceramide PC-102	1,3-bis(N-2-(hydroxyethyl)lauroylamino)-2-hydroxy propane INCI Name : Hydroxypropyl Bislauramide MEA Powder, For Solubilizing product
Ceramide PC-107	1,3-bis(N-2-(hydroxyethyl)isostearoylamino)-2-hydroxy propane INCI Name : Hydroxypropyl Bisisostearamide MEA Skin lotion, Perfume product
Ceramide PC-108	1,3-bis(N-2-(hydroxyethyl)stearoylamino)-2-hydroxy propane
Tocomide	Tocopherol and ceramide conjugate INCI Name : Bis-Hydroxyethyl Tocopherylsuccinoylamido Hydroxypropane