Celkeran 2/5 Mg Tablet

With the support of our expert, our company is dedicated Trader, Exporter, Distributor and Supplier of Celkeran 2/5 Mg Tablet in Kurnool, Andhra Pradesh, India. Celkeran 2/5 Mg Tablet is a chemotherapy drug that has been mainly used in the treatment of chronic lymphocytic leukemia. It is a nitrogen mustard alkylating agent and can be given orally.Chlorambucil produces its anti-cancer effects by interfering with DNA replication and damaging the DNA in a cell. The DNA damage induces cell cycle arrest and cellular apoptosis via the accumulation of cytosolic p53 and subsequent activation of Bax, an apoptosis promoter.
Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, inducing DNA damage via three different methods of covalent adduct generation with double-helical DNA.
Attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA.
DNA damage via the formation of cross-links which prevents DNA from being separated for synthesis or transcription.
Induction of mispairing of the nucleotides leading to mutations.