Camptothecin - C20h16n2o4 | Light Yellow Crystal Powder, Superior Dna Topoisomerase I Inhibition

1.Natural Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.

2.In clinical camptothecin is widely believed that natural camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, camptothecin is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein cannot be synthesized, camptothecin ultimately causes cell death.

3.Application of camptothecin in clinic is limited due to serious side effects and poor water-solubility.

4.At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous therapy such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic.

Cas No.: 7689-03-4
MF: C20H16N2O4
MW: 348.35
Appearance: Light yellow crystal powder.