Brimonidine Tartrate - Cas No: 70359-46-5

5

3

10 Kilograms/Kilograms

25 Kilograms/Kilograms

25 Kilograms/Kilograms

C15H16BrN5O6

C15H16BrN5O6

C H BrN O

205-210

~205 C to 210 C (with decomposition)

205 C~210 C

Cabergoline

Brimonidine Tartrate

Brimonidine

70359-46-5

70359-46-5

70359-46-5

Antiglaucoma

Brimonidine Tartrate is primarily used in ophthalmology and dermatology for the following purposes:1. Glaucoma and Ocular HypertensionMechanism: It is an alpha-2 adrenergic receptor agonist.Action: Reduces intraocular pressure (IOP) by decreasing aqueous humor production and increasing uveoscleral outflow.Brand names: Commonly found in products like Alphagan .2. Facial Redness in RosaceaMechanism: Causes vasoconstriction of dilated facial blood vessels.Form: Typically used as a topical gel or cream.Brand names: Examples include Mirvaso .

Selective -adrenergic receptor agonist; used in ophthalmic preparations for glaucoma and ocular hypertension

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Asia, Australia, Central America, North America, South America, Eastern Europe, Western Europe, Middle East, Africa

Asia, Australia, Central America, North America, South America, Eastern Europe, Western Europe, Middle East, Africa

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615-013-4

274-584-5

The pH level of Brimonidine Tartrate formulations can vary depending on the specific product and its intended use. Here are some general ranges: For Eye Drop Formulations: The pH is typically adjusted to be close to 7.0 (neutral), often ranging from 4.5 to 6.5, to be compatible with the eye and prevent irritation. For Topical Gel: The pH might be slightly more acidic or closer to neutral, generally within the range of 4.5 to 6.0, to ensure both stability and skin compatibility. The pH is important for ensuring that the compound remains stable and non-irritating when used in pharmaceutical applications.

As per COA

29333990

29335990

For Brimonidine Tartrate, as with most pharmaceutical compounds, the presence of heavy metals is typically monitored to ensure safety and compliance with pharmacological standards. The heavy metal content is generally tested and controlled according to pharmacopoeial standards (such as the USP or EP). The limit for heavy metals in pharmaceutical-grade Brimonidine Tartrate is typically set to 10 ppm (parts per million) or 10 g/g in the final product, depending on the specific regulations in place. This is done to ensure that any potential contaminants from metals like lead (Pb), arsenic (As), cadmium (Cd), or mercury (Hg) are kept well below toxic levels.

As per COA

Brimonidine Tartrate is soluble in water and methanol, but its solubility in other solvents like ethanol and chloroform is limited. Here's a more detailed breakdown: Solubility in water: Freely soluble. Solubility in methanol: Freely soluble. Solubility in ethanol: Slightly soluble. Solubility in chloroform: Practically insoluble. Solubility in organic solvents: Low solubility in non-polar solvents. The solubility in water is especially important for its use in ophthalmic solutions and topical treatments, ensuring proper absorption and effectiveness.

Soluble in water; slightly soluble in alcohol

98%

99