Benazepril Hydrochloride By Uma Brothers

We are major trader and exporter of Benazepril Hydrochloride in Mumbai, Maharashtra, India. Benazepril hydrochloride is the hydrochloride salt of benazepril, a carboxyl-containing angiotensin-converting enzyme (ace) inhibitor with antihypertensive activity. As a prodrug,benazepril is metabolized to its active form benazeprilat. Benazeprilat competitively binds to and inhibits ace, thereby blocking the conversion of angiotensin I to angiotensin ii. This prevents the potent vasoconstrictive actions of angiotensin ii, resulting in vasodilation. Benazeprilat also decreases angiotensin ii-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. Benazepril is a prodrug which is metabolized by the liver into its active formbenazeprilat via cleavage of the drug's ester group.

SYNONYMS: 2-[(3S)-3-[[(2S)-1-ETHOXY-1-OXO-4-PHENYLBUTAN-2-YL] AMINO]-2-OXO-4, 5-DIHYDRO-3H-1-BENZAZEPIN-1-YL] ACETIC ACID; HYDROCHLORIDE
CAS NUMBER: 86541-74-4, MOL. FORMULA: C24H29ClN2O5, MOL.WEIGHT: 460.95
BENAZEPRIL HYDROCHLORIDE IS A WHITE CRYSTALLINE SOLID POWDER. IT IS SOLUBLE IN WATER (50 MM), DMSO (100 MM), ETHANOL, AND METHANOL WITH MELTING RANGE OF 188A C TO 190A C.
STANDARD: OFFERED OF PHARMACEUTICAL GRADE BP/USP/EP
PACKING: OFFERED IN EXPORT WORTHY PACKING OF 25 KILOS OR AS PER OUR CUSTOMER REQUIREMENTS