Urokinase - Urokinase-type Plasminogen Activator (Hmw-upa & Lmw-upa) | High Molecular Weight Enzyme For Plasminogen Conversion, Effective Cleavage Action

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Urokinase-type plasminogen activator
Other names: U-plasminogen activator,Cellular plasminogen activator,Urinary plasminogen activator,uPA, Urokinase,
Source: The urine of man
Uniprot ID: P00749
EC: 3.4.21.73
Average weight: HMW-uPA,about 54kDa; LMW-uPA,about 31kDa;
Description: Urokinase-type plasminogen activator converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Urokinase-type plasminogen activator is an enzyme that in human is encoded by the PLAU gene. This gene's proprotein is cleaved at a Lys-Ile(178-179) bond by plasmin to form a two-chain derivative in which a single disulfide bond(Cys168-Cys299) connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.