Thiocolchicoside - N-[1,2-dimethoxy-10-methylsulfanyl-9-oxo-3-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6,7-dihydro-5h-enzo[d]heptalen-7-yl]acetamide, Yellow Crystalline Powder, Gaba-a Antagonist With Myorelaxant Effects

Thiocolchicoside, a semi-synthetic derivative of the naturally occurring compound colchicoside extracted from the seeds of Gloriosa superba..Its Chemical name is N-[1,2-dimethoxy-10-methylsulfanyl-9-oxo-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6,7-dihydro-5H-enzo[d]heptalen-7-yl] acetamide and molecular formula C27H33NO10S . Thiocolchicoside is a Yellow crystalline Powder, soluble in water.

Gloriosa is a genus of five or six species in the plant family Colchicaceae, from tropical Africa and Asia. They are tender, tuberous rooted deciduous perennials, adapted to summer rainfall with a dormant dry season. Their native range is Africa, Southeastern Asia and parts of Malaysia, but they are now widely cultivated. Gloriosa superba is the national flower of Zimbabwe, former Rhodesia (where it is a protected plant). It is also the state flower of Tamilnadu state in India.

Pharmacology Thiocolchicoside binds to GABA-A and strychnine sensitive glycine receptors. Thiocolchicoside acting as a GABA-A receptor antagonist, its myorelaxant effects could be exerted at the via complex regulatory mechanisms, although a glycerin mechanism of action cannot be excluded. The characteristics of the interaction of Thiocolchicoside with GABA-A receptors are qualitatively and quantitatively shared by its main circulating metabolite, the glucuronidated Derivative.