Theophylline Api - Cas No: 58-55-9

84.21

180.16 Grams (g)

180.164 Grams (g)

Other

Room Temperature

Room Temperature

Theophylline

Theophylline

Pharmaceutical Intermediates

Pharmaceutical Intermediates

Other

Theophylline, also known as 1,3-dimethylxanthine, is a methylxanthine drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma under a variety of brand names.

Theophylline is primarily used in the treatment of respiratory conditions, particularly those involving bronchoconstriction. Here are the main uses:1. Asthma:Theophylline is used as a bronchodilator to relieve symptoms of asthma, particularly for chronic asthma or when other treatments are not sufficient.It works by relaxing the muscles around the airways, making it easier to breathe.Long-term management: It is generally used for maintenance therapy in asthma, particularly in combination with other medications like inhaled corticosteroids.2. Chronic Obstructive Pulmonary Disease (COPD):Theophylline is used to relieve symptoms of COPD (including chronic bronchitis and emphysema), such as shortness of breath and wheezing.It improves airflow by dilating the airways and helping to clear mucus.3. Apnea of Prematurity (in Neonates):Theophylline is used in premature infants to treat apnea of prematurity. This is a condition where premature infants stop breathing for short periods.Theophylline helps stimulate respiratory drive and improves breathing patterns in neonates.4. Chronic Bronchitis:Chronic bronchitis, often associated with COPD, is a condition where the airways are inflamed and narrowed. Theophylline helps dilate the airways and ease breathing.5. Other Off-Label Uses:Theophylline may sometimes be used for other respiratory conditions, including pulmonary fibrosis or interstitial lung diseases, though it's less common today with newer medications available.Dosage and Administration:Oral Tablets: Theophylline is often given in extended-release form for once or twice-daily dosing.Injectable Form: For emergency situations or severe exacerbations of respiratory conditions.Oral Syrups or Solutions: For children or those who have difficulty swallowing tablets.Precautions:Narrow Therapeutic Range: Theophylline has a narrow therapeutic window, meaning the difference between a therapeutic dose and a toxic dose is small. Blood levels must be monitored regularly to avoid toxicity.Side Effects: Common side effects include insomnia, headaches, nausea, vomiting, and heart palpitations. High levels can lead to arrhythmias and seizures.Interactions: Theophylline interacts with several other medications, including certain antibiotics (like ciprofloxacin), antidepressants, and anticonvulsants, affecting its metabolism.Mechanism of Action:Theophylline works by inhibiting phosphodiesterase enzymes, leading to increased levels of cyclic AMP (cAMP), which relaxes the smooth muscles of the airways and opens up the air passages, making it easier to breathe.

MUMBAI

Mumbai

Nhava Sheva / Hazira

500 Per Week

1000 Per Day

1000 Per Week

25kg/drum with double plastic bags inside; packed in a cardboard drum or fiber HDPE drum.

25kgs

25 kg/drum with double plastic bags inside; packed in a cardboard drum or fiber HDPE drum.

All India

All India

3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione

Phenylephrine

Liquid

Powder

Free samples are available

Free samples available with shipping and taxes paid by the buyer