Tetanus Antitoxin By R. P. Enterprises

Tetanus Antitoxin

The goodwill, we have gained in the market is due to the Tetanus Antitoxin that is given to persons at the risk of tetanus infection caused by infected or severe wounds. Obtained from the reputed vendors of the market, this antitoxin is precisely formulated and has the desired substance that are used to neutralize the toxin formed by tetanus infection. Also, provided antitoxin is checked post processing process to ensure its maximum effectiveness. The offered Tetanus Antitoxin is available in various packaging options to meet the diverse needs of the clients at the most affordable price.

Product Features:

• Purity
• Precise composition
• No side effects
• Long shelf life

Tatanus Antitoxin is prepared by hyperimmunising horses with tetanus toxoid/toxin. Plasma from healthy immunized horses is enzyme refined, purified and concentrated. The tetanus antitoxin has the specific antitoxic globulins which neutralize the toxin formed by Clostridium tetani, the causative organism organism of Tetanus infection.

Route of Administration:
Subcutaneous or Intramuscular injection.

Administration:

• Tetanus antitoxin is given prophylactically to persons at the risk of tetanus infection by infected wounds or severe wounds. A dose of 1500 IU should be given intramuscularly or subcutaneously and the dose may be doubled or trebled in case multiple and severe wounds. Prophylactic dose is also given in surgical operations as post operative care.

• Along with this passive immunization it is advisable to initiate active immunization with adsorbed Tetanus toxoid.

Indications:
Tetanus antitoxin neutralizes the toxin produced by Clostridium tetani; the toxin has high affinity for new cells and antitoxin is unlikely to have an effect on toxin that is no longer circulating. Tetanus antitoxins have been used to provide temporary passive immunity against tetanus.

Contraindications:
Sensitivity testing (e.g., skin test, conjunctival test) should be conducted in all individuals, regardless of clinical history, prior to administration of tetanus antitoxin.

Serum Reaction:

• In case of patients receiving tetanus antitoxin serum, it should be essential to test for hypersensitivity of the individual with a test dose.

• Serum sensitivity test is carried out by injecting 0.1 ml serum in 1:10 dilution either subcutaneously or intracutaneously and observing for half an hour for any reactions of local or general. In case of hypersensitive reaction, serum should be given with great caution in small divided dose subcutaneously at regular intervals of half an hour. Injection adrenaline (1:1000) must be at hand for immediate treatment of shock, if it develops. Intravenous administration of serum is not recommended in hypersensitive cases.

• In some cases symptoms as itching, urticarial rash, pains in joints and muscles, fever, enlargement of lymph glands, appear about serium sickness last a few days and patients recover without any complication.

Storage:
The liquid Tetanus antitoxin should be stored between 2 ^oC to 8 ^oC. It should not be allowed to freeze. Freeze dried Tetanus antitoxin can be stored in a cool, dark place or in a refrigerator, if available. Reconstituted liquid should not be stored for a long time and should not be allowed to freeze.

Presentation:
Tetanus antitoxin is supplied as 1 ml liquid in glass vial/ampoule and also supplied as freeze dried powder with 1 ml of Water for Injection I.P. for reconstitution.