Nexavar Tablet - Targeted Therapy For Advanced Renal Cell Carcinoma And Hepatocellular Carcinoma, Effective Tyrosine Kinase Inhibitor And Angiogenesis Blocking Agent

Nexavar is a targeted therapy. Sorafenib is classified as a, Tyrosine Kinase inhibitor, Angiogenesis Inhibitor, VEGF inhibitor. (For more detail, see "How this drug works," below.)

What this drug is used for:
* Treatment of advanced renal cell cancer
* Hepatocellular carcinoma (HCC)

Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.

How this drug is given:
* As tablets by mouth.
* It is recommended that tablets are taken without food (at least 1 hour before or 2 hours after eating).
* The amount of sorafenib that you will receive depends on many factors. Your doctor will determine your exact dosage and schedule.

Side effects:
Important things to remember about the side effects of sorafenib:
* You will not get all of the side effects mentioned below.
* Side effects are often predictable in terms of their onset, duration, and severity.
* Side effects are almost always reversible and will go away after therapy is complete.
* Side effects are quite manageable. There are many options to minimize or prevent them.

The following side effects are common (occurring in greater than 30%) for patients taking sorafenib, when compared with those receiving placebo:

* Rash
* Hand - foot syndrome (Palmar-plantar erythrodysesthesia or PPE)