Irinotecan - C33h38n4o6 | 99% Assay, Yellow-osteoporosis Block For Cancer Treatment

We are offering our customers a wide range of Irinotecan, which are available following Specifications :-
Synonyms:
1,4'-bipiperidine-1'-carboxylic acid(s)-4,11-diethyl-3,4,12,14-tetrahydro-4-
hydroxy-3,14-dioxo-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester
Molecular formula: C33H38N4O6
Molecular weight: 586.69
Appearance: Flaxen to yellow osteoporosis block or powder
CAS: 97682-44-5
Assayi 99%
Indication: This product for the treatment of metastatic colorectal cancer, gastric cancer, esophageal cancer, extensive small cell lung cancer.
Pharmacology: Irinotecan is a semi-synthetic derivatives of camptothecin which can be specifically combined with the topoisomerase I. Topoisomerase I induced reversible single-strand breaks, so that double-stranded structure of DNA unwinded. Irinotecan and its active metabolite SN-38 with topoisomerase I-DNA complex binding, thereby preventing the fractured single-stranded nucleic acid to be connected. Existing research suggests that irinotecan cytotoxicity due to DNA synthesis process. Replicase and a topoisomerase I-DNA irinotecan (or SN-38) triple complex interactions, causing DNA double-strand breaks. Mammalian cells can not efficiently repair the DNA double-strand breaks.