Intermediates Acadesine

We are engaged in distributing excellent quality Intermediates Acadesine in Durban, KwaZulu Natal, South Africa.

CAS: 2627-69-2

Alias: AICAR;AICA-RIBOSIDE;AMPK;Z-RIBOSIDE
CAS: 2627-69-2
Assay: 98%
EINECS: 220-097-5
M.F.: C9H14N4O5
M.W.: 258.23
M.S.:

M.P.: 214-215 A C
Storage instructionsi Store at -20A C (desiccating conditions).
Solubility overviewi Soluble in water to 50 mM and in DMSO to 100 mM (with
heating)
Properties: white or off-white powder.
Usage: pharmaceutical intermediates.For the treatment of cardiovascular
diseases.

Functions:
AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.