Human Cyp2c19 Gene Polymorphism Detection Kit

We are specialized in exporting, manufacturing and supplying a huge spectrum of Human CYP2C19 Gene Polymorphism Detection Kit in Wuhan, Hubei, China. The cytochrome P450 (CYP) family of enzymes performs the primary metabolism of many drugs in the human body. One of these CYP enzymes, CYP2C19, is responsible for the metabolism of a wide variety of drugs including the anti-blood clotting drug Plavix (Clopidogrel). CYP2C19 is required to convert Plavix, a prodrug, to its active form. Patients who have poor CYP2C19 activities will not effectively convert Plavix to its active form. Plavix will have low efficacy in those patients in preventing heart attack, stroke, and cardiovascular death. The following represent the different alleles of CYP2C19 that make up a patient's genotype1:
a cThe CYP2C19*1 allele has fully functional metabolism of Plavix.
a cThe CYP2C19*2 and *3 alleles have no functional metabolism of Plavix. These two alleles account for most of the reduced function alleles in patients of Caucasian (85%) and Asian (99%) descent classified as poor metabolizers.
a cThe CYP2C19*4, *5, *6, *7, and *8 and other alleles may be associated with absent or reduced metabolism of Plavix, but are less frequent than the CYP2C19*2 and *3 alleles.
a cA patient with two loss-of-function alleles (as defined above) will have poor metabolizer status.