Colimista 1 Miu

The dose to be administered and the treatment duration should take into account the severity of the infection as well as the clinical response. Therapeutic guidelines should be adhered to. The dose is expressed in international units (IU) of colistimethate sodium (CMS). A conversion table from CMS in IU to mg of CMS as well as to mg of colistin base activity (CBA) is included at the end of this section. Posology The following dose recommendations are made based on limited population-pharmacokinetic data in critically ill patients (see section 4.4): Adults and adolescents Maintenance dose 9MIU/day in 2-3 divided doses In patients who are critically ill, a loading dose of 9 MIU should be administered. The most appropriate time interval to the first maintenance dose has not been established. Modelling suggests that loading and maintenance doses of up to 12 MIU may be required in patients with good renal function in some cases. Clinical experience with such doses is however extremely limited and safety has not been established. The loading dose applies to patients with normal and impaired renal functions including those on renal replacement therapy. Renal impairment Dose adjustments in renal impairment are necessary, but pharmacokinetic data available for patients with impaired renal function is very limited. The following dose adjustments are suggested as guidance.