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Fluconazole is primarily used to treat a variety of fungal infections. Its main uses include: 1. Yeast Infections: Vaginal Candidiasis (yeast infections): Fluconazole is commonly prescribed as a one-time dose for treating vaginal yeast infections caused by Candida species. Oropharyngeal and Esophageal Candidiasis: It treats fungal infections in the mouth and throat (thrush) as well as in the esophagus. Systemic Candidiasis: For severe infections affecting the bloodstream or internal organs. 2. Fungal Infections: Cryptococcal Meningitis: Fluconazole is used to treat fungal infections in the brain and spinal cord, typically caused by Cryptococcus species. It's commonly used in people with weakened immune systems, such as those with HIV/AIDS. Fungal Infections in Immunocompromised Patients: It s used to prevent fungal infections in patients with weakened immune systems, including those undergoing chemotherapy or organ transplants. 3. Preventive Use: In people with compromised immune systems, such as those undergoing chemotherapy, bone marrow transplants, or HIV/AIDS patients, fluconazole may be used to prevent fungal infections. 4. Other Fungal Infections: It can be used to treat other types of fungal infections, such as Blastomycosis, Coccidioidomycosis, and Histoplasmosis. Fluconazole works by inhibiting the growth of fungi by interfering with the synthesis of ergosterol, a vital component of fungal cell membranes.

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