Rombipra-ls Capsule

Domperidone is a medicine that increases the movements or contractions of the stomach and bowel. Domperidone is also used to treat nausea and vomitingA caused by other medicines. Levosulpiride is a prokinetic agent that increases the lower oesophageal sphincter pressure more rapidly and effectively than other therapeutic agents. The prokinetic effect of levosulpiride is mediated through the blockade of enteric dopamine D2receptors. Levosulpiride also acts as a moderate agonist at the 5-HT4 receptor. The serotonergic (5-HT4) component of levosulpiride may enhance its therapeutic efficacy in gastrointestinal disorders (helping reduce nausea and vomiting). This property, together with antagonism at D2A receptors, may contribute to its gastrointestinal prokinetic effect. The drug also exerts clinical anti-depressant effects/anti-psychotic effects by blocking the presynaptic dopaminergic D2receptors.