Albus-i Tablet

Ivermectin binds selectively and with a high affinity to glutamate-gated chloride ion channels in invertebrate muscle and nerve cells of the microfilaria. This binding causes an increase in the permeability of the cell membrane to chloride ions and results in hyperpolarization of the cell, leading to paralysis and death of the parasite. Ivermectin also is believed to act as an agonist of the neurotransmitter gamma-aminobutyric acid (GABA), thereby disrupting GABA-mediated central nervous system (CNS) neurosynaptic transmission. Ivermectin may also impair normal intrauterine development of O. volvulus microfilariae and may inhibit their release from the uteri of gravid female worms. Albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by diminishing its energy production. Ultimately leading to immobilization and death of the parasite.A A It works by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules.A A As cytoplasmic microtubules are critical in promoting glucose uptake in larval and adult stages of the susceptible parasites, the glycogen stores of the parasites are depleted.A A Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased adenosine triphosphate (ATP), which is the energy required for the survival of the helminth.