Methylprednisolone Dispersible Tablets

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Additional Information:MEPRED 4/8/16 MG TAB Methylprednisolone Dispersible Tablets-4mg,8mg.16mg Adrenal cortex synthesizes: Corticosteroids (glucocorticoids and mineralocorticoid). A A.Glucocorticoid effects on carbohydrate protein and fat metabolism and other activities. A A.Mineralocorticoid: effect on sodium potassium and fluid balance A A.The naturally occurring steroids have both anti inflammatory (glucocorticoids) and salt retaining (mineralocorticoid) properties. Hydrocortisone- mainly Glucocorticoid. Aldosterone- mainly mineralocorticoid. A A.The highest concentration occurs in the early morning and the lowest at midnight. Corticosteroids are similar in most metabolites effects. But differ in sodium retaining properties equivalent dosage, and biological half-life. Mechanism of action A A"The Glucocorticoid receptor is present in the cell cytoplasm which translocates to the nucleus after Glucocorticoid binding. In the nucleus the Glucocorticoid receptor binds to DNA at specific hormone receptor elements to start gene transcription. Pharmacology A A"Glucocorticoids are vital to the normal function of the human body. They help the organism with the capacity to resist stressful circumstances. Glucocorticoids cause profound and varied metabolic effects. Modify bodyAca a cs immune response to diverse stimuli. Pharmacokinetics A A"Hydrocortisone and its synthetic analogs are effective when given by orally. Certain water soluble hydrocortisone and its synthetic longeners are administered intravenously to achieve high concentration of drug rapidly in body fluids. More prolonged effects are obtained by intramuscular injection of suspensions of hydrocortisone and its esters. Indications Bronchial asthma Rheumatic disorder: Renal disease: Nephrotic syndrome. Bronchial asthma A A"Corticosteroids are frequently used in bronchial asthma they sometimes are employed in COPD.. A A"Inhaled glucocorticoids are effective in reducing bronchial hyper reactivity with less suppression of adrenal function than with oral glucocorticoids, A A"Pulmonary edema. A A"Autoimmune diseases A A"Autoimmune hemolytic anemia, thrombocytopenia, active chronic hepatitis responds to corticoids. A A"Ocular diseases A A"Used in inflammatory eye diseases, conjunctivitis, retinitis, optic neuritis. A A"Gastrointestinal diseases A A"Inflammatory bowel diseases like ulcerative colitis. A A"Skin diseases A A"Topical and systemic corticoids are widely used and are highly effective in many eczematous skin diseases. A A"Malignancies A A"Organ transplantation and skin allograft Adverse effects A A"Withdrawal can flare-up the underlying diseases. A A"The most severe complication of steroid cessation is acute adrenal insufficiency; result from too rapid withdrawal of corticosteroids after prolonged therapy. A A"Fluid and electrolyte: sodium and water retention, edema and hypertension A A"CushingAca a cs syndrome: characteristic appearance with rounded face, narrow mouth, and obesity of trunk with relatively thin limbs. A A"Hyperglycemia, precipitation of diabetes A A"Muscular weakness, Susceptibility of infection, Delayed heating of wounds and surgical incisions, Possible risk of peptic ulceration. A A"Osteoporosis A A"Cataract and Glaucoma A A"Growth retardation in children if given for long periods Dosage A A"Dose 4-48 mg orally/day