Tenofovir Disoproxil Fumarate Tablets - 300 Mg Each For Hiv-1 Treatment | Oral Administration, Renal Impairment Dosage Adjustments, Combination Therapy Usage

Each Tenofovir Disoproxil Fumarate Tablets contains: Tenofovir Disoproxil Fumarate 300 mg equivalent to Tenofovir Disoproxil : 245 mg

Indication:
For the treatment of HIV-1 infection (in combination with other antiretroviral agents).

Dosage and Administration:
The dose of Tenofovir is 300 mg once daily taken orally, without regard to food. Dose recommended in renal impairment: Creatinine clearance 30-49 mL/min: 300 mg every 48 hours Creatinine clearance 10-29 mL/min: 300 mg twice a week Hemodialysis: 300 mg every 7 days or after approximately 12 hours of dialysis

Contraindications:
Hypersensitivity to any of the components of the product.

Adverse Reactions:
Common: Rash, diarrhoea, flatulence, nausea, vomiting, asthenia. Serious: lactic acidosis, hepatitis B, hepatomegaly, with steatosis, immune hypersensitivity reaction, acute renal failure, fanconi syndrome, interstitial nephritis, nephrogenic diabetes insipidus, renal impairment, tubular necrosis.

Warnings & Precautions:
Lactic acidosis and severe hepatomegaly with steatosis have been reported with nucleoside analogues. Immune reconstitution syndrome has been reported in patients treated with combination antiretroviral therapy. Hepatitis B virus coinfection: risk for severe, acute exacerbations of HBV infection after discontinuation of tenofovir disoproxil fumarate.