Nebivolol Ip/bp/usp/ep Boiling Point: -

Niksan Pharmaceutical is worlda s top leading manufacturer, exporter, trader and supplier of Nebivolol API as well as finished pharmaceutical products of Nebivolol among the pharmaceutical companies. Our product Nebivolol is widely used and appreciated by our group companies and also our customers and users all around the nations. We offer the Nebivololin very affordable price.

Niksan Pharmaceutical and Niksan group companies are the very well-known manufacturer, supplier and distributor of Nebivolol products.

Niksan Pharmaceutical are manufacturing and exporting very large quantity of Nebivolol in countries like Hungary, El Salvador, Paraguay, Germany, Argentina, Austria, Romania, Pakistan, Portugal, Latvia, Philippines, Honduras, Switzerland, France, Chile, Estonia, North Macedonia, Lithuania, Guatemala, Croatia, Kenya, Ireland, Serbia, Belgium, Bulgaria, Bosnia & Herzegovina, Netherlands, Colombia, Dominican Republic, Bangladesh, Vietnam, Venezuela, Mexico, Brazil, Iraq, Bolivia, Ecuador, United Arab Emirates, Sri Lanka, Czechia, Australia, Jordan, Spain, Singapore, United Kingdom, Egypt, Slovakia, Greece, Peru, Nigeria, United States, Turkey, Malaysia, Poland, Algeria, Morocco, Hong Kong, Saudi Arabia, South Korea, Denmark, Taiwan, Finland, Thailand, Canada, Indonesia, Italy, Russia and many other countries.

Nebivolol comes in the beta blocker category of medicine. Usually Nebivolol used to treat the high blood pressure.
Nebivolol decrease the blood pressure by slowing the heart rate and by relaxing the muscles and blood vessels by this Nebivolol improve the blood flow. Usually Nebivolol is not the first choice medication but it is given when necessary.
SYNONYMS OF NEBIVOLOL: Narbivolol, Nebivolol, Nebivololum.
IUPAC NAME OF NEBIVOLOL: 1-(6-fluoro-3, 4-dihydro-2H-1-benzopyran-2-yl)-2-{[2-(6-fluoro-3, 4-dihydro-2H-1-benzopyran-2-yl)-2-hydroxyethyl] amino} ethan-1-ol
CAS NO: 118457-14-0
FORMULA: C22H25F2NO4
MOLECULAR MASS: 405.43 g/mol
STORAGE CONDITION: Store in room temperature in dry place, away from light and moisture. Do not put in fridge, kitchen or bathroom. Keep away from children and pets.

HOW TO USE: Take this medication one time per day orally with or without food. Take medication regularly to get more benefits of it, do not forget to take medication, take medication as soon you remember.

HOW NEBIVOLOL WORKS: Nebivolol is normally beta-1 adrenergic receptor antagonist which increases the blood flow and cardiac output by relaxing the blood vessels in the body. The effect of Nebivolol normally stays for 48 hrs.
PHARMACOKINETICS OF NEBIVOLOL: Normally Nebivolol absorbed orally and bind with the 98% of albumin. Nebivolol inhibits the btea-1-adrenargic receptor by this the blood flow increases in heart and body. The half-life of Nebivolol is generally 12hrs. Nebivolol normally excreted 38% by urination and 44% by faces.

SIDE EFFECTS OF NEBIVOLOL: The normal side effects like dizziness, headache, weakness, sloe heartbeat, nausea, insomnia are often seen in the patients. Nebivolol sometime cause reduces the blood flow to the feet so feet cold happens some time. If you see some serious side effects like blue figures/toes, fainting, slow heartbeats, mental/ mood swings.

PRECAUTIONS WHILE TAKING NEBIVOLOL: Before taking the Nebivolol tell your doctor if you are allergic to it. Tell your doctor if you have any problem like heart problem, blood circulation problem, breathing problem, liver/kidney problem. Kindly avoid taking medicines if you are in pregnancy period. Before taking the medication tell your doctor if you taking the other medication or having past disease. If the side effects seen worsen kindly contact to your doctor.

CDSCO APPROVAL: Nebivolol + Hydrochlorthiazide approved by CDSCO in Indian in 23.12.2004, Indapamide (SR) 1.5mg/1.5mg + Nebivolol 2.5mg/5mg tabletapproved by CDSCO in Indian in 12.05.2010,
Amlodipine (5mg) + Nebivolol (5mg) tablet (addl. Strength)approved by CDSCO in Indian in 06.09.2007,
Nebivolol 5mg + S(-) Amlodipine 2.5mg Tabletapproved by CDSCO in Indian in 14.09.2004,
Nebivolol (as HCl) 5mg + Valsartan 80mg Capsule approved by CDSCO in Indian in 25.01.2006,
Nebivolol tabs & bulk import approved by CDSCO in Indian in 12.07.2002.

FORMULATIONS AVAILABLE IN MARKET:
Nebivolol 5mg tablets
Nebivolol 10mg tablets
Nebivolol 2.5mg tablets
Nebivolol 5mg + Amlodipine 5mg tablets
Nebivolol 5mg + Cilnidipine 10mg tablets
Nebivolol 5mg +Valsartan 80mg tablets
Nebivolol 5mg + Telmisartan 40 mg tablets

Note: Product protected by valid patents are not offered for sale in countries where such patents are still valid and its liability is at Buyers Risk.

REFERENCES:

www.webmd.com
https://pubchem.ncbi.nlm.nih.gov
https://go.drugbank.com
https://cdscoonline.gov.in
https://www.wikipedia.org/
https://www.drugs.com
https://www.zaubacorp.com
https://www.practo.com/consult