Esomeprazole is a proton pump inhibitor which is used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and Zollinger-Ellison syndrome.
Esomeprazole is the S-enantiomer of omeprazole and AstraZeneca claims improved efficacy of this single enantiomer product over the racemic mixture of omeprazole. However, this greater efficacy has been disputed, with some claiming it offers no benefit from its older form.
Esomeprazole is a proton pump inhibitor which reduces acid secretion through inhibition of ATPase in gastric parietal cells. By inhibiting the functioning of this enzyme, the drug prevents formation of gastric acid.
Our "STABICOAT Omeprazole Pellets" shows above 90% of gastric fluid resistance. This means that 90% of Omeprazole is protected in stomach, which ensures required quantity of drug is available for release in intestine.
High GF resistance of our product is assisted by high dissolution in intestine fluid. Minimum 85% of the drug is dissolved within 45 minutes.
Loss on Drying:
LOD is another important parameter for Omeprazole pellets - less is better. Higher moisture content results in faster deterioration of the drug. Our product comes with less than 2% of LOD.
Our "Omeprazole Enteric Coated Granules" comes with good compressive strength, which minimizes the possibility of breakage. This makes handling of the granules during filling up of the capsules easy and trouble free.
Smoothness & shining:
High quality coating materials and advanced coating technology ensure smooth and shining surface of the granules. This makes the granules free flowing for easy operation of capsule filling. Shining helps in visual checking of the granules for its proper coating as well as in differentiating from uncoated granules.
Methacrylic acid polymer and HPMC Pthalate are the two most suitable enteric coating materials for Omeprazole. We use any of these two as per the specific requirement of the customer.
We can provide the products as per customers' specifications. However, our typical specifications are given below.
Stability And Storage : It is physically and chemically stable when stored in original packing in dry place at below 25A C protected from light.
Available as : 8.5% and 22.5% or as per requirement
Packing : 15 kg, 20 kg, 25 kg, 30 kg or multiple of 1 kg active equivalent
Specification : 8.5%
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