Duolin Respules By C. B. Pharma

Each 2.5 ml unit-dose vial contains:

Levosalbutamol Sulphatea a a a a a .1.25 mg

Ipratropium Bromide a a a a a a a a 500 mcg

Normal Saline Solution, IP a a a a a ............q.s.
Dosage Form

Solution for inhalation via a nebulizer.
Description

DUOLIN Respules is a combination of the beta2-adrenergic bronchodilator, levosalbutamol sulphate, and the anticholinergic bronchodilator, ipratropium bromide.

Levosalbutamol sulphate is a relatively selective beta2-adrenergic agonist, whose activation leads to an increase in intracellular adenyl cyclase, the enzyme which catalyses the conversion of adenosine triphosphate (ATP) to cyclic-3`, 5`-adenosine monophosphate (cAMP).

Ipratropium bromide is an anticholinergic (parasympatholytic) agent, which inhibits vagally-mediated reflexes by antagonizing the action of acetylcholine, the transmitter agent released from the vagus nerve.

DUOLIN Respules.......... available as respule of 2.5 ml