Ivabradine Ip/bp/ep/usp Application: Medicine

Niksan Pharmaceuticalis an Ankleshwar based company who manufacture, supply, and export and distribute the very fine quality of Ivabradine API along with Ivabradine formulations. Our product Ivabradine is widely appreciated by our group companies and also by our clients. Niksan Pharmaceutical manufactures best quality product of Ivabradine in the best WHO GMP certified manufacture facilities. And provides all required documents of the drug we manufacture.
Niksan Pharmaceutical export large quantity of the IvabradineAPI and Ivabradine formulation worldwide since many years in countries like Myanmar (Burma), Lebanon, Sri Lanka, Singapore, Philippines, United Arab Emirates, Ireland, Pakistan, United Kingdom, India, Malaysia, Australia, Iraq, Lithuania, Jordan, Vietnam, Egypt, Bangladesh, Saudi Arabia, Hong Kong ,Netherlands, Taiwan, Latvia, Kenya, Hungary, Thailand, Slovakia, France, South Korea, Canada, Greece, Israel, Romania, New Zealand, Poland, United States, South Africa, Morocco, Belgium, Indonesia, Iran, Sweden, Italy, Germany, Turkey, Spain, Russia, Japan, Brazil and many more countries.

Niksan Pharmaceuticalmanufacture and provides best quality of Ivabradine in all over Indian states like Delhi, Tamil Nadu, Odisha, Maharashtra, West Bengal, Uttar Pradesh, Gujarat, Madhya Pradesh, Andhra Pradesh, Haryana, Telangana, Bihar, Karnataka, Jammu andKashmir, Kerala, Punjab, Rajasthan in large quantity.

Ivabradine is one drug belongs to the cardiotonic medicines. The Ivabradine commonly used in the treatment of heart failure and also used in the treatment of chest pain caused by irregular heartbeats problem.

Ivabradine inhibits the pace maker current by this process Ivabradine reduces the heart rate. Ivabradine is different from the beta blockers calcium channel blockers.

SYNONYM OF IVABRADINE: Ivabradin, Ivabradina, Ivabradine, Ivabradinum.

IUPAC NAME :3-[3-({[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino)propyl]-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one

CAS NO: 155974-00-8

MOLECULAR FORMULA:C27H36N2O5

MOLECULAR MASS: 468.58 g/mol

STORAGE OF IVABRADINE: Store the medication in a room temperature.Put medication away from light and moisture.Keep medication away of reach of children and pet.

HOW TO USE:Take these medications twice a day with food as directed by your doctor.If you are using the liquid medication of Ivabradine kindly read the directions written on the container label. Take this medicine regularly to achieve more benefit of Ivabradin.Kindly take your doctora s advice if our condition does no improve.

HOW IVABRADINE WORKS: Ivabradine used in the treatment of chest pain and also used as antianginal agent. Ivabradine reduces the heart rate by inhibiting the pace maker current in heart by this the heart rate will become slower.Ivabradine also use in the treatment of enlarged heart in children.it is also use to prevent of heart failure.

PHARMACOKINETICS OF IVABRADINE:Ivabradine will be rapidly absorbed orally. It reaches the peak plasma level in about 1 hr. the absolute bioavaibility of Ivabradine is 40% in liver and gut.The half-life of Ivabradine is about 2 hours.Almost 70% Ivabradine bound with the plasma protein.About 4% of unchanged drug is excreted by urination and the total body clearance rate of v is 24 l/h.And the metabolites will excrete by urination as well as in feces.

SIDE EFFECTS OF IVABRADINE:Dizziness and tiredness are the most common side effects of the Ivabradine.There are also some rare side effects like seeing of coloured lights, increase in brightness is also shown by the Ivabradine.Consult your doctor if you feel fainting or slow decreased heart beats.Sometime some allergic reactions like itching, swelling of longue, throat and rash like symptoms are also caused by Ivabradin.

PRECAUTIONS OF IVABRADINE: If you have any lung problem, heart problem or any liver problem, tell your doctor before taking the prescription.Tell your doctor if you are allergic to the Ivabradine or its residues.This drug may cause you dizziness, blurred vision so after taking the medicine do not operate any machinery and dona t drive vehicles.If you are taking alcohol or cannabis tell your doctor about it.

CDSCO APPROVAL: Ivabradine (HCL) 5mg/7.5mg Tablets are approved by CDSCO in India in 03.07.2008,
Ivabradine HCL Tablets 5mg/7.5mg (Additional indication) tablet is approved by CDSCO in Indian in 19.12.2013, Ivabradine HCL Tablets 5/7.5mg (Additional Indication) tablet is approved by CDSCO in India in 10.02.2010,
Ivabradine Tablets 5mg/7.5mg (Additional Indication) tablet approved by CDSCO in Indian in 05.05.2011

FORMULATIONS AVAILABLE IN MARKET:
Ivabradine 2.5 mg tablets
Ivabradine 5mg tablets
Ivabradine10 mg tablets
Ivabradine7.5 mg tablets
Ivabradine HCL 5mg tablets
Ivabradine HCL 7.5mg tablets
Ivabradine 5mg + Metoprolol 25mg tablets
Ivabradine 5mg + Metoprolol 50mg tablets

Note: Product protected by valid patents are not offered for sale in countries where such patents are still valid and its liability is at Buyers Risk

REFERENCES:

www.webmd.com
https://pubchem.ncbi.nlm.nih.gov
https://go.drugbank.com
https://cdscoonline.gov.in
https://www.wikipedia.org/
https://www.drugs.com
https://www.zaubacorp.com
https://www.practo.com/consult