Artemether
Posted on: 7th April 2009
[India]
Artemisinin (pronounced ) is a drug used to treat multi-drug resistant strains of falciparum malaria. The compound (a sesquiterpene lactone) is isolated from the shrub Artemisia annua long used in traditional Chinese medicine. Not all shrubs of this species contain artemisinin. Apparently it is only produced when the plant is subjected to certain conditions, most likely biotic or abiotic stress. I
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Primaquine
Posted on: 7th April 2009
[India]
Primaquine (or primaquine phosphate) is a medication used in the treatment of malaria and Pneumocystis pneumonia. It is a member of the 8-aminoquinoline group of drugs that includes pamaquine.
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Quinine Hydrochloride
Posted on: 7th April 2009
[India]
In addition to its anti-malarial properties, quinine is an effective muscle relaxant, long used by the Quechua Indians of Peru to halt shivering brought on by cold temperatures. The Jesuit Brother Agostino Salumbrino (1561-1642), an apothecary by training and who lived in Lima, observed the Quechua using the quinine-containing bark of the cinchona tree for that purpose. While its effect in treatin
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Amodiaquine Base
Posted on: 7th April 2009
[India]
Artemisinin is under early research and testing for treatment of cancer, primarily by researchers at the University of Washington. Artemisinin has a peroxide lactone group in its structure. It is thought that when the peroxide comes into contact with high iron concentrations (common in cancerous cells), the molecule becomes unstable and releases reactive oxygen species. It has been shown to reduce
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Amodiaquine Hydrochloride
Posted on: 7th April 2009
[India]
Amodiaquine has been shown to be more effective than chloroquine in treating CRPF (chloroquine-resistant Plasmodium falciparum) malaria infections and may afford more protection than chloroquine when used as weekly prophylaxis. Amodiaquine, like chloroquine, is generally well tolerated. Although licensed, this drug is not marketed in the United States but is widely available in Africa. Its use, th
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Artensunate
Posted on: 7th April 2009
[India]
Artemisinin is under early research and testing for treatment of cancer, primarily by researchers at the University of Washington.[5][6] Artemisinin has a peroxide lactone group in its structure. It is thought that when the peroxide comes into contact with high iron concentrations (common in cancerous cells), the molecule becomes unstable and releases reactive oxygen species. It has been shown to
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Sertraline Hydrochloride
Posted on: 7th April 2009
[India]
Sertraline hydrochloride (trade names Zoloft, Lustral) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It was introduced to the market by Pfizer in 1991. Sertraline is primarily used to treat clinical depression in adult outpatients as well as obsessive-compulsive, panic and social anxiety disorders in both adults and children. In 2007 it was the most prescribed an
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Phenazone Salicylate
Posted on: 7th April 2009
[India]
Propyphenazone or Isopropylantipyrine (C14H18N2O, 1,2-dihydro-1,5-dimethyl-4-(isopropyl)-2-phenyl-pyrazol-3-one) is a derivative of phenazone with similar analgesic and antipyretic effects.
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Propacetamol Hydrochloride
Posted on: 7th April 2009
[India]
Propacetamol is a prodrug form of paracetamol which is formed from esterification of paracetamol, and the carboxylic acid Diethylglycin. This has the advantage of making it more water soluble. It is used in post-operative care and is delivered by I.V.. [2] It is given if the patient is unable to take oral or rectally delivered paracetamol and non-steroidal anti-inflammatory drugs are contraindicat
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Dichloralphenazone
Posted on: 7th April 2009
[India]
Dichloralphenazone is a 1:2 mixture of antipyrine with chloral hydrate. In combination with paracetamol and isometheptene, it is the active ingredient of medications for migraine and vascular (tension) headaches, including Epidrin and Midrin. Performance impairments are common with this drug and caution is advised, for example when driving motor vehicles. This drug acts on the blood vessels in the
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Mesalamine
Posted on: 7th April 2009
[India]
Mesalazine (INN, BAN), also known as Mesalamine (USAN) or 5-aminosalicylic acid (5-ASA), is an anti-inflammatory drug used to treat inflammation of the digestive tract (Crohn's disease) and mild to moderate ulcerative colitis. Mesalazine is a bowel-specific aminosalicylate drug that is metabolized in the gut and has its predominant actions there, thereby having fewer systemic side effects.
As a
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Bisoprolol Fumarate
Posted on: 7th April 2009
[India]
Bisoprolol had an antihypertensive effect in all hypertension models investigated. Bisoprolol reduced the blood pressure in conscious dogs with renal hypertension, accompanied by only a slight decrease in heart rate. In comparison with bisoprolol, propranolol had a weaker antihypertensive effect even at a considerably higher dose level [12]. Bisoprolol also reduced the blood pressure in rats with
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Phenazone
Posted on: 7th April 2009
[India]
Phenazone, or phenazon, is an analgesic. It was first synthesised by Ludwig Knorr in 1883. It is formed by reducing diortho-dinitrodiphenyl with sodium amalgam and methyl alcohol, or by heating diphenylene-ortho-dihydrazine with hydrochloric acid to 150 C. It crystallizes in needles which melt at 156 C. Potassium permanganate oxidizes it to pyridazine tetracarboxylic acid.
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Isopropylantipyrine
Posted on: 7th April 2009
[India]
Propyphenazone or Isopropylantipyrine (C14H18N2O, 1,2-dihydro-1,5-dimethyl-4-(isopropyl)-2-phenyl-pyrazol-3-one) is a derivative of phenazone with similar analgesic and antipyretic effects.
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Analgin
Posted on: 7th April 2009
[India]
Metamizole was banned in Sweden in 1974, in the United States in 1977; more than 30 countries, including Japan, Australia, Iran, and part of the European Union, have followed suit. In these countries metamizole is still occasionally used as a veterinary drug. In Germany it became a prescription drug. Some European pharmaceutical companies, notably Hoechst and Merck, continue to develop metamizole-
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Dipyrone
Posted on: 7th April 2009
[India]
According to comments by Dr Anthony Wong of the University of So Paulo, Brazil in a WHO newsletter,[1] recent studies estimate that the incidence rate of metamizole-induced agranulocytosis is between 0.2 and 2 cases per million person days of use, with approximately 7% of all cases fatal (provided that all patients have access to urgent medical care). In other words, one should expect 50 to 500 de
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Metformin Hydrochloride
Posted on: 7th April 2009
[India]
Metformin (INN; trade names Glucophage, Riomet, Fortamet, Glumetza, Diabex, Diaformin, and others) (IPA: /m?t'f?rm?n/) is an oral anti-diabetic drug from the biguanide class. It is the first-line drug of choice for the treatment of type 2 diabetes, particularly in overweight and obese people and those with normal kidney function.[1][2][3] Metformin is the most popular anti-diabetic drug in the Uni
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Propyphenazone
Posted on: 7th April 2009
[India]
Propyphenazone or Isopropylantipyrine (C14H18N2O, 1,2-dihydro-1,5-dimethyl-4-(isopropyl)-2-phenyl-pyrazol-3-one) is a derivative of phenazone with similar analgesic and antipyretic effects.
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Metamizole Sodium
Posted on: 7th April 2009
[India]
Metamizole sodium is a non-steroidal anti-inflammatory drug (NSAID), commonly used in many countries as a powerful painkiller and fever reducer. It is better known under the names Dipyrone, Analgin, Novalgin, and Melubrin.
Metamizole was first synthesized by the German company Hoechst AG (now part of Sanofi-Aventis) in 1920, and its mass production started in 1922. It remained freely available
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Metoprolol Tartrate
Posted on: 7th April 2009
[India]
Metoprolol is a selective beta1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially hypertension. It is marketed under the brand name Lopressor or Lopresor, respectively, by Novartis, and Toprol-XL (in the USA); Selokeen (in Nederlands); as Minax by Alphapharm (in Australia), Metrol by Arrow Pharmaceuticals (in Australia), as Betaloc by AstraZeneca, as N
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Arteether
Posted on: 7th April 2009
[India]
Artemisia has been used by Chinese herbalists for more than a thousand years in the treatment of many illnesses, such as skin diseases and malaria. The earliest record dates back to 200 BC , in the "Fifty two Prescriptions" unearthed from the Mawangdui Han Dynasty Tombs. Its antimalarial application was first described in Zhouhou Beji Fang ("The Handbook of Prescriptions for Emergencies"), edited
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Amodiaquine
Posted on: 7th April 2009
[India]
Amodiaquine (trade names Camoquin, Flavoquine) is a 4-aminoquinoline compound related to chloroquine, used as an antimalarial and anti-inflammatory agent. Amodiaquine has been shown to be more effective than chloroquine in treating CRPF (chloroquine-resistant Plasmodium falciparum) malaria infections and may afford more protection than chloroquine when used as weekly prophylaxis. Amodiaquine, like
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Dihydroartemisinin
Posted on: 7th April 2009
[India]
Dihydroartemisinin is available as a fixed drug combination with piperaquine (each tablet contains 40 mg of dihydroartemisinin and 320 mg of piperaquine; trade name Artekin, manufactured by Holleykin Pharmaceuticals). The adult dose is 1.6/12.8 mg/kg per dose (rounded up or down to the nearest half tablet) given at 0 h, 8 h, 24 h, and 48 h. Alternatively, the same total dose may be given once dail
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Antipyrine
Posted on: 7th April 2009
[India]
Antipyretics are drugs that reduce body temperature in situations such as fever. However, they will not affect the normal body temperature if one does not have fever
Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever.
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Amodiaquine Hcl
Posted on: 7th April 2009
[India]
Amodiaquine has been shown to be more effective than chloroquine in treating CRPF (chloroquine-resistant Plasmodium falciparum) malaria infections and may afford more protection than chloroquine when used as weekly prophylaxis. Amodiaquine, like chloroquine, is generally well tolerated. Although licensed, this drug is not marketed in the United States but is widely available in Africa. Its use, th
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