CLINICAL PHARMACOLOGY Artesunate is a potent blood schizonticide agent for P. falciparum. It is effective against P. falciparum resistant to all other antimalarial drugs. It does not have hypnozoiticidal activity. It reduces gametocyte carriage rate. Artesunate binds tightly to parasitized erythrocyte membranes. The functional group responsible for antimalarial activity of artesunate is endoperoxide bond. Release of an active oxygen species from this bond kills the parasite if accumulated in the erythrocytic cells. It also suppresses the production or activity of antioxidant enzymes

Pharmacology Pharmacodynamics Glimepiride The primary mechanism of action of glimepiride in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells. In addition, extrapancreatic effects may also play a role in the activity of sulphonylureas such as glimepiride. Metformin Metformin is an oral antihyperglyacemic drug used in the management of type 2 diabetes. It improves glucose tolerance in patients with type 2 diabetes (NIDDM), lowering both basal and postprandial plasma glucose. Metfo

BECLOCIN-O Ear Drops Composition: Beclometha. Dipropi. 0.025 % w/v, Clotrimazole 1.0 % w/v Chloramphenicol 5.0 % w/v, Lignocaine Hcl 2.0 % w/v Presentation: 10 ml. Pack. Beclomethasone:Potent Steroid Clotrimazole : Powerful Antifungal Chloramphenicol: Anti Becterial Lignocaine Hcl : Anesthatic Agent OQN Ear Drops Beclomethasone Dipropionate Clotrimazole Chloramphenicol Lignocaine Hcl OPAT Eye Drops Olopetadine Hydrochloride Ophthalmic Solution

Ceftriaxone (INN) (pronounced) is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to cefotaxime in terms of safety and efficacy. Ceftriaxone is often used (in combination, but not direct, with macrolide and/or aminoglycoside antibiotics) for the treatment of community-acquired or mild to moderate health care-associated pneumonia. It is also a choice drug for treatment of bacterial meningitis. In pediatrics, it is