CLINICAL PHARMACOLOGY Artesunate is a potent blood schizonticide agent for P. falciparum. It is effective against P. falciparum resistant to all other antimalarial drugs. It does not have hypnozoiticidal activity. It reduces gametocyte carriage rate. Artesunate binds tightly to parasitized erythrocyte membranes. The functional group responsible for antimalarial activity of artesunate is endoperoxide bond. Release of an active oxygen species from this bond kills the parasite if accumulated in the erythrocytic cells. It also suppresses the production or activity of antioxidant enzymes in

Pharmacodynamics Amlodipine Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Experimental data suggest that amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectivel

BECLOCIN-O Ear Drops Composition: Beclometha. Dipropi. 0.025 % w/v, Clotrimazole 1.0 % w/v Chloramphenicol 5.0 % w/v, Lignocaine Hcl 2.0 % w/v Presentation: 10 ml. Pack. Beclomethasone:Potent Steroid Clotrimazole : Powerful Antifungal Chloramphenicol: Anti Becterial Lignocaine Hcl : Anesthatic Agent

Tigo-8 Tablets offer Betahistine 8 mg. Betahistine hydrochloride is the generic name for the anti vertigo drug SERC. It was first registered in Europe in 1970 for the treatment of disease. It is commonly prescribed for people who have balance disorders or to alleviate the vertigo symptoms associated with diseases. Betahistine is available in 8 mg. tablets. It is contraindicated for people with peptic ulcers or tumours of the adrenal gland. People with bronchial asthma should be closely monitored. Pharmacology Betahistine comes in tablet form and is taken orally. It is rapidly and compl

Ceftriaxone (INN) (pronounced) is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to cefotaxime in terms of safety and efficacy. Ceftriaxone is often used (in combination, but not direct, with macrolide and/or aminoglycoside antibiotics) for the treatment of community-acquired or mild to moderate health care-associated pneumonia. It is also a choice drug for treatment of bacterial meningitis. In pediatrics, it is c